Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 460361..460928 Replicon chromosome
Accession NC_010513
Organism Xylella fastidiosa M12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag XFASM12_RS01940 Protein ID WP_004085174.1
Coordinates 460361..460642 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag XFASM12_RS01945 Protein ID WP_012337645.1
Coordinates 460653..460928 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFASM12_RS01910 456223..457815 - 1593 WP_012337641.1 tail fiber domain-containing protein -
XFASM12_RS01915 457823..458380 - 558 WP_012337642.1 phage tail protein I -
XFASM12_RS01920 458373..459266 - 894 WP_012337643.1 baseplate J/gp47 family protein -
XFASM12_RS01925 459266..459604 - 339 WP_004088650.1 GPW/gp25 family protein -
XFASM12_RS01930 459712..459993 + 282 WP_004087027.1 XRE family transcriptional regulator -
XFASM12_RS01935 460005..460304 + 300 WP_004087025.1 HigA family addiction module antidote protein -
XFASM12_RS01940 460361..460642 + 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFASM12_RS01945 460653..460928 + 276 WP_012337645.1 HigA family addiction module antidote protein Antitoxin
XFASM12_RS01950 460933..461520 - 588 WP_012337646.1 phage baseplate assembly protein V -
XFASM12_RS01955 461517..462059 - 543 WP_012337647.1 hypothetical protein -
XFASM12_RS01960 462035..462556 - 522 WP_012337648.1 hypothetical protein -
XFASM12_RS01965 462553..462876 - 324 WP_012337649.1 hypothetical protein -
XFASM12_RS01970 462876..463136 - 261 WP_012337650.1 hypothetical protein -
XFASM12_RS01975 463154..465028 - 1875 WP_012337651.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 446909..481283 34374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T22751 WP_004085174.1 NC_010513:460361-460642 [Xylella fastidiosa M12]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T22751 NC_010513:460361-460642 [Xylella fastidiosa M12]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTTGTGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCGCTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTACCACTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9982.56 Da        Isoelectric Point: 10.2184

>AT22751 WP_012337645.1 NC_010513:460653-460928 [Xylella fastidiosa M12]
MKRMHNPAHPGEVLREYLGDLTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQAKYDLWVASQ
QPRPKITRLHV

Download         Length: 276 bp

>AT22751 NC_010513:460653-460928 [Xylella fastidiosa M12]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGATCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTCGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGGCCAAGTATGACCTGTGGGTTGCTAGCCAG
CAGCCACGCCCGAAGATCACACGTCTTCATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References