Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4969892..4970304 Replicon chromosome
Accession NZ_CP089032
Organism Escherichia coli O157:H7 strain 6535WT

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag LSI69_RS25360 Protein ID WP_000132630.1
Coordinates 4969963..4970304 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4969892..4969968 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSI69_RS25350 (4966519) 4966519..4967988 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
LSI69_RS25355 (4967988) 4967988..4969742 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4969892) 4969892..4969968 - 77 NuclAT_15 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_15 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_15 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_15 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_16 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_16 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_16 - Antitoxin
- (4969892) 4969892..4969968 - 77 NuclAT_16 - Antitoxin
LSI69_RS25360 (4969963) 4969963..4970304 + 342 WP_000132630.1 endoribonuclease SymE Toxin
LSI69_RS25365 (4970351) 4970351..4971514 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
LSI69_RS25370 (4971562) 4971562..4972443 - 882 WP_001304007.1 DUF262 domain-containing protein -
LSI69_RS25375 (4972586) 4972586..4972738 - 153 WP_001418365.1 hypothetical protein -
LSI69_RS25380 (4972881) 4972881..4974293 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4962091..4983318 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T227484 WP_000132630.1 NZ_CP089032:4969963-4970304 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T227484 NZ_CP122923:207560-207667 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 bp

>AT227484 NZ_CP089032:c4969968-4969892 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References