Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4705405..4705817 Replicon chromosome
Accession NZ_CP089031
Organism Escherichia coli strain 7386Nal

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag CO543_RS23730 Protein ID WP_000132630.1
Coordinates 4705476..4705817 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4705405..4705481 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO543_RS23720 (4702032) 4702032..4703501 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
CO543_RS23725 (4703501) 4703501..4705255 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4705405) 4705405..4705481 - 77 NuclAT_14 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_14 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_14 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_14 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_15 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_15 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_15 - Antitoxin
- (4705405) 4705405..4705481 - 77 NuclAT_15 - Antitoxin
CO543_RS23730 (4705476) 4705476..4705817 + 342 WP_000132630.1 endoribonuclease SymE Toxin
CO543_RS23735 (4705864) 4705864..4707027 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
CO543_RS23740 (4707075) 4707075..4707956 - 882 WP_001304007.1 DUF262 domain-containing protein -
CO543_RS23745 (4708099) 4708099..4708251 - 153 WP_001418365.1 hypothetical protein -
CO543_RS23750 (4708394) 4708394..4709806 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4697604..4718819 21215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T227457 WP_000132630.1 NZ_CP089031:4705476-4705817 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T227457 NZ_CP122880:186348-186455 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 bp

>AT227457 NZ_CP089031:c4705481-4705405 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References