Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 57411..58138 | Replicon | plasmid p49210-229.3 |
| Accession | NZ_CP089030 | ||
| Organism | Klebsiella pneumoniae strain 49210 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | LRY78_RS28775 | Protein ID | WP_011251285.1 |
| Coordinates | 57827..58138 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRY78_RS28770 | Protein ID | WP_011251286.1 |
| Coordinates | 57411..57830 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRY78_RS28740 (LRY78_28730) | 52579..53049 | - | 471 | WP_048333570.1 | hypothetical protein | - |
| LRY78_RS28745 (LRY78_28735) | 53362..53997 | - | 636 | WP_223171879.1 | hypothetical protein | - |
| LRY78_RS28750 (LRY78_28740) | 54416..55036 | + | 621 | WP_223175004.1 | conjugative transfer protein MobI(A/C) | - |
| LRY78_RS28755 (LRY78_28745) | 55057..55845 | + | 789 | WP_040217257.1 | hypothetical protein | - |
| LRY78_RS28760 (LRY78_28750) | 55859..56224 | + | 366 | WP_048333448.1 | hypothetical protein | - |
| LRY78_RS28765 (LRY78_28755) | 56296..57264 | - | 969 | WP_086642568.1 | IS5 family transposase | - |
| LRY78_RS28770 (LRY78_28760) | 57411..57830 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LRY78_RS28775 (LRY78_28765) | 57827..58138 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LRY78_RS28780 (LRY78_28770) | 58343..58780 | - | 438 | Protein_59 | DDE-type integrase/transposase/recombinase | - |
| LRY78_RS28785 (LRY78_28775) | 58915..59612 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
| LRY78_RS28790 (LRY78_28780) | 59614..60063 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| LRY78_RS28795 (LRY78_28785) | 60080..60391 | + | 312 | WP_011251282.1 | hypothetical protein | - |
| LRY78_RS28800 (LRY78_28790) | 60405..60746 | + | 342 | WP_011251281.1 | hypothetical protein | - |
| LRY78_RS28805 (LRY78_28795) | 60806..61762 | + | 957 | WP_011251280.1 | DsbA family protein | - |
| LRY78_RS28810 (LRY78_28800) | 61879..62454 | + | 576 | WP_074424927.1 | hypothetical protein | - |
| LRY78_RS28815 (LRY78_28805) | 62562..63077 | + | 516 | WP_041937820.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA | 1..229288 | 229288 | |
| - | inside | IScluster/Tn | - | - | 47292..59612 | 12320 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T227424 WP_011251285.1 NZ_CP089030:c58138-57827 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T227424 NZ_CP122872:771951-772247 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT227424 WP_011251286.1 NZ_CP089030:c57830-57411 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT227424 NZ_CP122872:772249-772644 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|