Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 58677..59401 | Replicon | plasmid p53370-97.9 |
| Accession | NZ_CP089022 | ||
| Organism | Klebsiella pneumoniae strain 53370 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2J4YLV3 |
| Locus tag | LRZ76_RS26705 | Protein ID | WP_023292165.1 |
| Coordinates | 58677..58988 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRZ76_RS26710 | Protein ID | WP_049010942.1 |
| Coordinates | 58985..59401 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRZ76_RS26660 (LRZ76_26660) | 53888..54319 | + | 432 | WP_004152657.1 | conjugation system SOS inhibitor PsiB | - |
| LRZ76_RS26665 (LRZ76_26665) | 54316..55038 | + | 723 | WP_022631512.1 | plasmid SOS inhibition protein A | - |
| LRZ76_RS26670 (LRZ76_26670) | 55042..55365 | + | 324 | WP_004199367.1 | hypothetical protein | - |
| LRZ76_RS26675 (LRZ76_26675) | 55476..55850 | + | 375 | WP_050584024.1 | hypothetical protein | - |
| LRZ76_RS26680 (LRZ76_26680) | 55926..56222 | + | 297 | WP_023317812.1 | hypothetical protein | - |
| LRZ76_RS26685 (LRZ76_26685) | 56878..57150 | + | 273 | WP_231820013.1 | hypothetical protein | - |
| LRZ76_RS26690 (LRZ76_26690) | 57147..57497 | + | 351 | WP_104513727.1 | hypothetical protein | - |
| LRZ76_RS26695 (LRZ76_26695) | 58129..58335 | + | 207 | WP_023317814.1 | hypothetical protein | - |
| LRZ76_RS26700 (LRZ76_26700) | 58346..58570 | + | 225 | WP_023317815.1 | hypothetical protein | - |
| LRZ76_RS26705 (LRZ76_26705) | 58677..58988 | + | 312 | WP_023292165.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LRZ76_RS26710 (LRZ76_26710) | 58985..59401 | + | 417 | WP_049010942.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LRZ76_RS26715 (LRZ76_26715) | 60238..60591 | + | 354 | WP_023317817.1 | hypothetical protein | - |
| LRZ76_RS26720 (LRZ76_26720) | 60648..60995 | + | 348 | WP_094338768.1 | hypothetical protein | - |
| LRZ76_RS26725 (LRZ76_26725) | 61089..61235 | + | 147 | WP_004152750.1 | hypothetical protein | - |
| LRZ76_RS26730 (LRZ76_26730) | 61286..62119 | + | 834 | WP_231820015.1 | N-6 DNA methylase | - |
| LRZ76_RS26735 (LRZ76_26735) | 62938..63759 | + | 822 | WP_231820042.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | qnrB4 / blaDHA-1 | - | 1..97945 | 97945 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12497.32 Da Isoelectric Point: 9.9242
>T227402 WP_023292165.1 NZ_CP089022:58677-58988 [Klebsiella pneumoniae]
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
VHVISRAPFDEAARHYPNDAAAIDDTYRVLKRVVAKKPDELKRYFTSLDRMKYREKWWVIDIGGNNLRMMFFADFERGKI
FVKHITTHAEYDRLTKYYREHKE
Download Length: 312 bp
>T227402 NZ_CP122868:886485-886892 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15438.52 Da Isoelectric Point: 4.4711
>AT227402 WP_049010942.1 NZ_CP089022:58985-59401 [Klebsiella pneumoniae]
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
MIFSDAIKAANDLASIVPLLGGSSSRKDYEEALKLVEYLLEHDPDSPLVDMLTARIDAWEDNAVEFEEFNTRIEAGKNGV
SLLRVLMQQHGLSQSDFENEIGKKSLVSRILSGERSLTLDHMRALANRFQIPVSMFVD
Download Length: 417 bp
>AT227402 NZ_CP122868:886238-886504 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|