Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 110215..110942 | Replicon | plasmid p49088-279.2 |
| Accession | NZ_CP089000 | ||
| Organism | Klebsiella pneumoniae strain 49088 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | LRZ82_RS28170 | Protein ID | WP_011251285.1 |
| Coordinates | 110631..110942 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRZ82_RS28165 | Protein ID | WP_011251286.1 |
| Coordinates | 110215..110634 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRZ82_RS28140 (105669) | 105669..106907 | + | 1239 | Protein_125 | copper/silver sensor histidine kinase SilS | - |
| LRZ82_RS28145 (106940) | 106940..107908 | + | 969 | WP_004225014.1 | IS5 family transposase | - |
| LRZ82_RS28150 (108242) | 108242..108649 | + | 408 | WP_227630754.1 | hypothetical protein | - |
| LRZ82_RS28155 (108663) | 108663..109028 | + | 366 | WP_048333448.1 | hypothetical protein | - |
| LRZ82_RS28160 (109100) | 109100..110068 | - | 969 | WP_086642568.1 | IS5 family transposase | - |
| LRZ82_RS28165 (110215) | 110215..110634 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LRZ82_RS28170 (110631) | 110631..110942 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LRZ82_RS28175 (111147) | 111147..111584 | - | 438 | Protein_132 | DDE-type integrase/transposase/recombinase | - |
| LRZ82_RS28180 (111719) | 111719..112416 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
| LRZ82_RS28185 (112418) | 112418..112867 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| LRZ82_RS28190 (112884) | 112884..113195 | + | 312 | WP_011251282.1 | hypothetical protein | - |
| LRZ82_RS28195 (113209) | 113209..113550 | + | 342 | WP_011251281.1 | hypothetical protein | - |
| LRZ82_RS28200 (113610) | 113610..114566 | + | 957 | WP_011251280.1 | DsbA family protein | - |
| LRZ82_RS28205 (114683) | 114683..115258 | + | 576 | WP_074424927.1 | hypothetical protein | - |
| LRZ82_RS28210 (115366) | 115366..115881 | + | 516 | WP_094819131.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-65 / fosA3 / blaTEM-1B / rmtB / blaKPC-2 / catA2 | iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA | 1..279210 | 279210 | |
| - | inside | IScluster/Tn | - | - | 106985..112416 | 5431 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T227310 WP_011251285.1 NZ_CP089000:c110942-110631 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
>T227310 NZ_CP122832:c4550306-4550133 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT227310 WP_011251286.1 NZ_CP089000:c110634-110215 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT227310 NZ_CP122832:c4550630-4550334 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|