Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 336965..337551 Replicon chromosome
Accession NZ_CP088985
Organism Klebsiella pneumoniae strain 53334

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LRZ83_RS01575 Protein ID WP_002920800.1
Coordinates 337183..337551 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LRZ83_RS01570 Protein ID WP_004174006.1
Coordinates 336965..337186 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRZ83_RS01550 (LRZ83_01550) 333122..334048 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LRZ83_RS01555 (LRZ83_01555) 334045..335322 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LRZ83_RS01560 (LRZ83_01560) 335319..336086 + 768 WP_073557610.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LRZ83_RS01565 (LRZ83_01565) 336088..336801 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LRZ83_RS01570 (LRZ83_01570) 336965..337186 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LRZ83_RS01575 (LRZ83_01575) 337183..337551 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LRZ83_RS01580 (LRZ83_01580) 337824..339140 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LRZ83_RS01585 (LRZ83_01585) 339247..340134 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LRZ83_RS01590 (LRZ83_01590) 340131..340976 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LRZ83_RS01595 (LRZ83_01595) 340978..342048 + 1071 WP_016946109.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 334045..342785 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T227217 WP_002920800.1 NZ_CP088985:337183-337551 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T227217 NZ_CP122801:183638-183745 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT227217 WP_004174006.1 NZ_CP088985:336965-337186 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT227217 NZ_CP122801:c183590-183524 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References