Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2307138..2307745 Replicon chromosome
Accession NZ_CP088952
Organism Massilia sp. DM-R-R2A-13

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LSQ66_RS10235 Protein ID WP_231769673.1
Coordinates 2307476..2307745 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LSQ66_RS10230 Protein ID WP_231769672.1
Coordinates 2307138..2307455 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSQ66_RS10220 (LSQ66_10220) 2303237..2305990 + 2754 WP_231769670.1 TonB-dependent receptor -
LSQ66_RS10225 (LSQ66_10225) 2306033..2307118 - 1086 WP_231769671.1 SGNH/GDSL hydrolase family protein -
LSQ66_RS10230 (LSQ66_10230) 2307138..2307455 - 318 WP_231769672.1 HigA family addiction module antitoxin Antitoxin
LSQ66_RS10235 (LSQ66_10235) 2307476..2307745 - 270 WP_231769673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSQ66_RS10240 (LSQ66_10240) 2307794..2309059 - 1266 WP_231769674.1 alpha/beta fold hydrolase -
LSQ66_RS10245 (LSQ66_10245) 2309062..2311407 - 2346 WP_231769675.1 TonB-dependent receptor -
LSQ66_RS10250 (LSQ66_10250) 2311534..2312601 - 1068 WP_231769676.1 non-reducing end alpha-L-arabinofuranosidase family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-64)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10094.44 Da        Isoelectric Point: 7.1642

>T227164 WP_231769673.1 NZ_CP088952:c2307745-2307476 [Massilia sp. DM-R-R2A-13]
MAIQSFACIDTETLFTTGKSRRFANIKSAAERKLAQLDAAPSLNFMKAPPGNDLKEYDGAWHVRINDQWRLTFKWGPNGP
YDVLIEDPH

Download         Length: 270 bp

>T227164 NZ_CP122758:c584497-584033 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11566.52 Da        Isoelectric Point: 10.0574

>AT227164 WP_231769672.1 NZ_CP088952:c2307455-2307138 [Massilia sp. DM-R-R2A-13]
MFKNGMRPVHPGEILLEDYIKPMGVSVRSVALALHVPYSRLSEIIKGERGVTADTALRLERYFGSEAQGWLNLQSAYDLR
TAEMTAGKAIAKVIKPLARDKAIPA

Download         Length: 318 bp

>AT227164 NZ_CP122758:c584832-584497 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References