Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/MqsA(antitoxin) |
Location | 3910757..3911342 | Replicon | chromosome |
Accession | NZ_CP088935 | ||
Organism | Thauera sp. WB-2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | LQF09_RS17855 | Protein ID | WP_002925880.1 |
Coordinates | 3910757..3911071 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LQF09_RS17860 | Protein ID | WP_002925881.1 |
Coordinates | 3911061..3911342 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LQF09_RS17825 (LQF09_17835) | 3906619..3907362 | + | 744 | WP_002928874.1 | urea ABC transporter ATP-binding protein UrtD | - |
LQF09_RS17830 (LQF09_17840) | 3907381..3908070 | + | 690 | WP_002928872.1 | urea ABC transporter ATP-binding subunit UrtE | - |
LQF09_RS17835 (LQF09_17845) | 3908092..3909324 | + | 1233 | WP_270068592.1 | acetamidase/formamidase family protein | - |
LQF09_RS17840 (LQF09_17850) | 3909408..3909752 | + | 345 | WP_270068593.1 | zinc ribbon domain-containing protein | - |
LQF09_RS17845 (LQF09_17855) | 3909845..3910096 | + | 252 | WP_270068594.1 | ribbon-helix-helix domain-containing protein | - |
LQF09_RS17850 (LQF09_17860) | 3910093..3910425 | + | 333 | WP_270068595.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
LQF09_RS17855 (LQF09_17865) | 3910757..3911071 | + | 315 | WP_002925880.1 | hypothetical protein | Toxin |
LQF09_RS17860 (LQF09_17870) | 3911061..3911342 | + | 282 | WP_002925881.1 | helix-turn-helix domain-containing protein | Antitoxin |
LQF09_RS17865 (LQF09_17875) | 3911824..3912072 | + | 249 | WP_002928853.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
LQF09_RS17870 (LQF09_17880) | 3912069..3912482 | + | 414 | WP_270068596.1 | type II toxin-antitoxin system VapC family toxin | - |
LQF09_RS17875 (LQF09_17885) | 3912613..3913650 | + | 1038 | WP_270068597.1 | aliphatic amidase | - |
LQF09_RS17880 (LQF09_17890) | 3913735..3914532 | + | 798 | WP_270068598.1 | CbbQ/NirQ/NorQ/GpvN family protein | - |
LQF09_RS17885 (LQF09_17895) | 3914516..3916186 | + | 1671 | WP_270068599.1 | VWA domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 3904424..3914532 | 10108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11613.20 Da Isoelectric Point: 8.9606
>T227160 WP_002925880.1 NZ_CP088935:3910757-3911071 [Thauera sp. WB-2]
MRTVAETAIFQRYASEIWSEAERAEFINWIAANPEAGDVIRGSGGCRKVRWTSAGQGKRGGARIIYFNANTETIWLLIAY
KKAKFDNLPTSFLAELKQGVEDAL
MRTVAETAIFQRYASEIWSEAERAEFINWIAANPEAGDVIRGSGGCRKVRWTSAGQGKRGGARIIYFNANTETIWLLIAY
KKAKFDNLPTSFLAELKQGVEDAL
Download Length: 315 bp
>T227160 NZ_CP122728:50872-51150 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGACGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAATGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGACGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAATGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10435.95 Da Isoelectric Point: 8.8537
>AT227160 WP_002925881.1 NZ_CP088935:3911061-3911342 [Thauera sp. WB-2]
MPSEIEKFQQDLLESVKQMRRGEAVRTTRVELSEAAEARAKMGLSQQAFADLLGVSARTLQEWEQGRRSPTGAAKTLLRV
AVSHPEVLQELRM
MPSEIEKFQQDLLESVKQMRRGEAVRTTRVELSEAAEARAKMGLSQQAFADLLGVSARTLQEWEQGRRSPTGAAKTLLRV
AVSHPEVLQELRM
Download Length: 282 bp
>AT227160 NZ_CP122728:50603-50872 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCACGGCGATGTGCTTCCTCATGACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCACGGCGATGTGCTTCCTCATGACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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