Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 3910757..3911342 Replicon chromosome
Accession NZ_CP088935
Organism Thauera sp. WB-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQF09_RS17855 Protein ID WP_002925880.1
Coordinates 3910757..3911071 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQF09_RS17860 Protein ID WP_002925881.1
Coordinates 3911061..3911342 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF09_RS17825 (LQF09_17835) 3906619..3907362 + 744 WP_002928874.1 urea ABC transporter ATP-binding protein UrtD -
LQF09_RS17830 (LQF09_17840) 3907381..3908070 + 690 WP_002928872.1 urea ABC transporter ATP-binding subunit UrtE -
LQF09_RS17835 (LQF09_17845) 3908092..3909324 + 1233 WP_270068592.1 acetamidase/formamidase family protein -
LQF09_RS17840 (LQF09_17850) 3909408..3909752 + 345 WP_270068593.1 zinc ribbon domain-containing protein -
LQF09_RS17845 (LQF09_17855) 3909845..3910096 + 252 WP_270068594.1 ribbon-helix-helix domain-containing protein -
LQF09_RS17850 (LQF09_17860) 3910093..3910425 + 333 WP_270068595.1 type II toxin-antitoxin system RelE/ParE family toxin -
LQF09_RS17855 (LQF09_17865) 3910757..3911071 + 315 WP_002925880.1 hypothetical protein Toxin
LQF09_RS17860 (LQF09_17870) 3911061..3911342 + 282 WP_002925881.1 helix-turn-helix domain-containing protein Antitoxin
LQF09_RS17865 (LQF09_17875) 3911824..3912072 + 249 WP_002928853.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LQF09_RS17870 (LQF09_17880) 3912069..3912482 + 414 WP_270068596.1 type II toxin-antitoxin system VapC family toxin -
LQF09_RS17875 (LQF09_17885) 3912613..3913650 + 1038 WP_270068597.1 aliphatic amidase -
LQF09_RS17880 (LQF09_17890) 3913735..3914532 + 798 WP_270068598.1 CbbQ/NirQ/NorQ/GpvN family protein -
LQF09_RS17885 (LQF09_17895) 3914516..3916186 + 1671 WP_270068599.1 VWA domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3904424..3914532 10108


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(37-81)


Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11613.20 Da        Isoelectric Point: 8.9606

>T227160 WP_002925880.1 NZ_CP088935:3910757-3911071 [Thauera sp. WB-2]
MRTVAETAIFQRYASEIWSEAERAEFINWIAANPEAGDVIRGSGGCRKVRWTSAGQGKRGGARIIYFNANTETIWLLIAY
KKAKFDNLPTSFLAELKQGVEDAL

Download         Length: 315 bp

>T227160 NZ_CP122728:50872-51150 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGACGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAATGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTGTAT
ATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10435.95 Da        Isoelectric Point: 8.8537

>AT227160 WP_002925881.1 NZ_CP088935:3911061-3911342 [Thauera sp. WB-2]
MPSEIEKFQQDLLESVKQMRRGEAVRTTRVELSEAAEARAKMGLSQQAFADLLGVSARTLQEWEQGRRSPTGAAKTLLRV
AVSHPEVLQELRM

Download         Length: 282 bp

>AT227160 NZ_CP122728:50603-50872 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCCCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCACGGCGATGTGCTTCCTCATGACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References