Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 535600..535967 Replicon chromosome
Accession NZ_CP088935
Organism Thauera sp. WB-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQF09_RS02385 Protein ID WP_270069080.1
Coordinates 535600..535791 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQF09_RS02390 Protein ID WP_270069081.1
Coordinates 535803..535967 (+) Length 55 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF09_RS02360 (LQF09_02360) 530869..531447 + 579 WP_004248804.1 TIGR01841 family phasin -
LQF09_RS02365 (LQF09_02365) 531760..533208 + 1449 WP_270069076.1 hypothetical protein -
LQF09_RS02370 (LQF09_02370) 533543..534916 + 1374 WP_270069077.1 integrase family protein -
LQF09_RS02375 (LQF09_02375) 534999..535277 + 279 WP_270069078.1 type II toxin-antitoxin system RelE/ParE family toxin -
LQF09_RS02380 (LQF09_02380) 535288..535596 + 309 WP_270069079.1 HigA family addiction module antitoxin -
LQF09_RS02385 (LQF09_02385) 535600..535791 + 192 WP_270069080.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQF09_RS02390 (LQF09_02390) 535803..535967 + 165 WP_270069081.1 helix-turn-helix transcriptional regulator Antitoxin
LQF09_RS02395 (LQF09_02395) 536068..537168 + 1101 WP_270069082.1 hypothetical protein -
LQF09_RS02400 (LQF09_02400) 537294..537521 + 228 WP_270069083.1 hypothetical protein -
LQF09_RS02405 (LQF09_02405) 537522..537887 + 366 WP_270069084.1 hypothetical protein -
LQF09_RS02410 (LQF09_02410) 537884..538459 + 576 WP_270069085.1 hypothetical protein -
LQF09_RS02415 (LQF09_02415) 538456..540018 + 1563 WP_270069086.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(4-49)

Antitoxin

Cro/C1-type helix-turn-helix domain

(1-39)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6629.89 Da        Isoelectric Point: 9.4485

>T227155 WP_270069080.1 NZ_CP088935:535600-535791 [Thauera sp. WB-2]
MTELAALKARILANPYTRAMGDGLFEIRAKGQEGIGRALFCTVVGKRIVQPLPSCCAPASVPA

Download         Length: 192 bp

>T227155 NZ_CP122727:2691471-2691578 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 55 a.a.        Molecular weight: 5918.86 Da        Isoelectric Point: 10.6061

>AT227155 WP_270069081.1 NZ_CP088935:535803-535967 [Thauera sp. WB-2]
MAERMGVSQPVVARIEGSIGSRKHAPSLATLRKYADACGQRLVIRFEPKQEHAA

Download         Length: 165 bp

>AT227155 NZ_CP122727:c2691424-2691358 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References