Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 460072..460679 Replicon chromosome
Accession NZ_CP088922
Organism Rhodanobacter denitrificans strain FW104-10B01

Toxin (Protein)


Gene name higB Uniprot ID I4WTS9
Locus tag LRK54_RS02155 Protein ID WP_007510671.1
Coordinates 460365..460679 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LRK54_RS02150 Protein ID WP_015447258.1
Coordinates 460072..460350 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRK54_RS02125 (LRK54_02125) 457669..458010 - 342 WP_007512800.1 lipid-A-disaccharide synthase N-terminal domain-containing protein -
LRK54_RS02135 (LRK54_02135) 458305..459069 - 765 WP_027489849.1 hypothetical protein -
LRK54_RS02140 (LRK54_02140) 459134..459496 - 363 WP_015447260.1 hypothetical protein -
LRK54_RS02145 (LRK54_02145) 459585..460016 + 432 WP_027489850.1 Arc family DNA-binding protein -
LRK54_RS02150 (LRK54_02150) 460072..460350 - 279 WP_015447258.1 helix-turn-helix domain-containing protein Antitoxin
LRK54_RS02155 (LRK54_02155) 460365..460679 - 315 WP_007510671.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRK54_RS02160 (LRK54_02160) 461151..464882 - 3732 WP_027489851.1 diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-81)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11641.42 Da        Isoelectric Point: 9.8349

>T227139 WP_007510671.1 NZ_CP088922:c460679-460365 [Rhodanobacter denitrificans]
MIFVETPIFTAQIKDLLSDDDYGAFQRYLAENPEAGDVIKETGGLRKIRVAAKGHGKSGGARVIYYYFVSASRIAMVFAY
PKNVQENLTPAQKAALKKVIEQWR

Download         Length: 315 bp

>T227139 NZ_CP122723:90432-90584 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10263.75 Da        Isoelectric Point: 7.2060

>AT227139 WP_015447258.1 NZ_CP088922:c460350-460072 [Rhodanobacter denitrificans]
MFDNLMESVTQMDEIVRGERQPSREVHIDALAVKEIRRATGLSQAKFAGIVDVQVGTLRNWEQGRREPTGPAKALLRAIS
KDPKHVLEALAD

Download         Length: 279 bp

>AT227139 NZ_CP122723:c90377-90320 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A154QK28

Antitoxin

Source ID Structure

References