Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_31
Location 3405293..3405894 Replicon chromosome
Accession NZ_CP088282
Organism Bradyrhizobium quebecense strain 12S5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag J4P68_RS16300 Protein ID WP_207833638.1
Coordinates 3405293..3405616 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag J4P68_RS16305 Protein ID WP_207833640.1
Coordinates 3405613..3405894 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4P68_RS16290 (J4P68_0016290) 3400836..3403175 - 2340 WP_207833635.1 mechanosensitive ion channel -
J4P68_RS16295 (J4P68_0016295) 3403495..3405225 + 1731 WP_207833636.1 ATP-dependent Clp protease adaptor ClpS -
J4P68_RS16300 (J4P68_0016300) 3405293..3405616 + 324 WP_207833638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4P68_RS16305 (J4P68_0016305) 3405613..3405894 + 282 WP_207833640.1 helix-turn-helix transcriptional regulator Antitoxin
J4P68_RS16310 (J4P68_0016310) 3405941..3408018 - 2078 Protein_3243 tetratricopeptide repeat protein -
J4P68_RS16315 (J4P68_0016315) 3408316..3408780 + 465 WP_207833642.1 Rrf2 family transcriptional regulator -
J4P68_RS16320 (J4P68_0016320) 3408767..3409597 + 831 WP_224924683.1 class I SAM-dependent methyltransferase -
J4P68_RS16330 (J4P68_0016330) 3410482..3410649 - 168 WP_207833644.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11932.99 Da        Isoelectric Point: 10.5452

>T227076 WP_207833638.1 NZ_CP088282:3405293-3405616 [Bradyrhizobium quebecense]
MSWSVEILNEVVVEEIAALPADMQARFIRLSERISAAGLESLGEPHVKHLVGKLWELRLTGRDGIARALYVTAFGRRVVV
VRAFVKKSQKTPPGEIELALRRAKEVT

Download         Length: 324 bp

>T227076 NZ_CP122712:2070903-2071154 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10105.78 Da        Isoelectric Point: 10.9985

>AT227076 WP_207833640.1 NZ_CP088282:3405613-3405894 [Bradyrhizobium quebecense]
MTIPFEKLKARLLANPKVRAEYDALAPEFEIAAELLKARQRAGLSQSELAAKMGTSQSTIARLESGQTLPSTKTLLRFAK
ATGSKFQIRLSAA

Download         Length: 282 bp

>AT227076 NZ_CP122712:2071151-2071405 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References