Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2271515..2272226 Replicon chromosome
Accession NZ_CP088265
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LRS40_RS12375 Protein ID WP_156264453.1
Coordinates 2271903..2272226 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LRS40_RS12370 Protein ID WP_142486806.1
Coordinates 2271515..2271859 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS12330 (LRS40_12330) 2266821..2267327 - 507 WP_142486811.1 ferritin-like domain-containing protein -
LRS40_RS12335 (LRS40_12335) 2267359..2267853 - 495 WP_106994953.1 ferritin-like domain-containing protein -
LRS40_RS12340 (LRS40_12340) 2267946..2268131 - 186 WP_103180815.1 general stress protein -
LRS40_RS12345 (LRS40_12345) 2268717..2269235 + 519 WP_231313802.1 hypothetical protein -
LRS40_RS12350 (LRS40_12350) 2269300..2269473 - 174 WP_166183533.1 hypothetical protein -
LRS40_RS12355 (LRS40_12355) 2269554..2270117 - 564 WP_231313803.1 hypothetical protein -
LRS40_RS12360 (LRS40_12360) 2270179..2270616 - 438 WP_231313804.1 hypothetical protein -
LRS40_RS12365 (LRS40_12365) 2271089..2271439 + 351 WP_231313805.1 type II toxin-antitoxin system HicB family antitoxin -
LRS40_RS12370 (LRS40_12370) 2271515..2271859 - 345 WP_142486806.1 HigA family addiction module antitoxin Antitoxin
LRS40_RS12375 (LRS40_12375) 2271903..2272226 - 324 WP_156264453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRS40_RS12380 (LRS40_12380) 2272439..2273332 - 894 WP_231313806.1 PhzF family phenazine biosynthesis protein -
LRS40_RS12385 (LRS40_12385) 2273480..2273863 + 384 WP_231313807.1 VOC family protein -
LRS40_RS12390 (LRS40_12390) 2273886..2274572 - 687 WP_231313808.1 RluA family pseudouridine synthase -
LRS40_RS12395 (LRS40_12395) 2274716..2275192 - 477 WP_142486801.1 DMT family transporter -
LRS40_RS12400 (LRS40_12400) 2275197..2275631 - 435 WP_142486800.1 DMT family transporter -
LRS40_RS12405 (LRS40_12405) 2275732..2276679 + 948 WP_231313809.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(10-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-71)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12227.11 Da        Isoelectric Point: 10.1298

>T227022 WP_156264453.1 NZ_CP088265:c2272226-2271903 [Leclercia sp. G3L]
MTTPLTLRSISDFRDTWLEDFFLYGRPHGKIPAEIASALMRKLDIINAATSYRDLRSPPGNKLEALSSPLLGCYSIRVNR
QYRLIFIWSGGKAKGIYLDPHTYNAHR

Download         Length: 324 bp

>T227022 NZ_CP122679:c3963840-3963442 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13134.04 Da        Isoelectric Point: 6.3288

>AT227022 WP_142486806.1 NZ_CP088265:c2271859-2271515 [Leclercia sp. G3L]
MAFTNSTRKPTTPGDILLHEFLEPLHLKIADLAEMLNVHRNSVSALVNNNRKLTTDMAVRLARAFDTTIEFWLNLQLNVD
IWEIQHDERMQAEHQQIITAAEMVERKKAQQSVA

Download         Length: 345 bp

>AT227022 NZ_CP122679:c3964136-3963843 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References