Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1220935..1221540 Replicon chromosome
Accession NZ_CP088265
Organism Leclercia sp. G3L

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LRS40_RS07170 Protein ID WP_231313405.1
Coordinates 1220935..1221249 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LRS40_RS07175 Protein ID WP_156264963.1
Coordinates 1221250..1221540 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS40_RS07140 (LRS40_07140) 1216091..1216690 + 600 WP_142487610.1 glucose-1-phosphatase -
LRS40_RS07145 (LRS40_07145) 1216684..1217565 + 882 WP_231313401.1 virulence factor BrkB family protein -
LRS40_RS07150 (LRS40_07150) 1217562..1217999 + 438 WP_231313402.1 D-aminoacyl-tRNA deacylase -
LRS40_RS07155 (LRS40_07155) 1218044..1218985 + 942 WP_185902396.1 fatty acid biosynthesis protein FabY -
LRS40_RS07160 (LRS40_07160) 1219052..1219612 - 561 WP_231313403.1 Ail/Lom family outer membrane beta-barrel protein -
LRS40_RS07165 (LRS40_07165) 1219780..1220706 - 927 WP_231313404.1 alpha/beta hydrolase -
LRS40_RS07170 (LRS40_07170) 1220935..1221249 + 315 WP_231313405.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRS40_RS07175 (LRS40_07175) 1221250..1221540 + 291 WP_156264963.1 NadS family protein Antitoxin
LRS40_RS07180 (LRS40_07180) 1221580..1222509 - 930 WP_142487602.1 formate dehydrogenase accessory protein FdhE -
LRS40_RS07185 (LRS40_07185) 1222506..1223141 - 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
LRS40_RS07190 (LRS40_07190) 1223138..1224040 - 903 WP_142487601.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12191.19 Da        Isoelectric Point: 9.6565

>T227019 WP_231313405.1 NZ_CP088265:1220935-1221249 [Leclercia sp. G3L]
MLFIETDIFTEDVKKLLDDDEYHKLQVFLAMQPEYGDLIQNTGGLRKIRWLAGGKGGKRSGVRVIYSYRSRENEIRLLLI
YRKGIKDDLSANEKAVLKMIIERW

Download         Length: 315 bp

>T227019 NZ_CP122679:3325723-3326109 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCACTAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10631.20 Da        Isoelectric Point: 11.0200

>AT227019 WP_156264963.1 NZ_CP088265:1221250-1221540 [Leclercia sp. G3L]
MDKALFERLTQSVAQMNEIAGGKREPSRTFQIDAMKIKEIRQASGLSQSKFAQLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT227019 NZ_CP122679:3326099-3326428 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References