Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3560525..3561261 Replicon chromosome
Accession NZ_CP088244
Organism Stenotrophomonas maltophilia strain 2013-SM4

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LQ335_RS16420 Protein ID WP_111175727.1
Coordinates 3560983..3561261 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQ335_RS16415 Protein ID WP_111175729.1
Coordinates 3560525..3560839 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ335_RS16395 (LQ335_16395) 3557088..3557648 + 561 WP_134968750.1 hypothetical protein -
LQ335_RS16400 (LQ335_16400) 3557882..3558808 + 927 WP_134968751.1 2OG-Fe(II) oxygenase -
LQ335_RS16405 (LQ335_16405) 3559538..3559801 - 264 WP_134968752.1 hypothetical protein -
LQ335_RS16410 (LQ335_16410) 3560127..3560396 + 270 WP_134968753.1 hypothetical protein -
LQ335_RS16415 (LQ335_16415) 3560525..3560839 - 315 WP_111175729.1 HigA family addiction module antitoxin Antitoxin
LQ335_RS16420 (LQ335_16420) 3560983..3561261 - 279 WP_111175727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ335_RS16425 (LQ335_16425) 3561458..3561826 - 369 Protein_3210 DNA methyltransferase -
LQ335_RS16430 (LQ335_16430) 3562122..3563174 + 1053 WP_134968755.1 tyrosine-type recombinase/integrase -
LQ335_RS16440 (LQ335_16440) 3563479..3564432 + 954 WP_134968754.1 DUF2268 domain-containing putative Zn-dependent protease -
LQ335_RS16445 (LQ335_16445) 3564530..3565195 - 666 WP_061480332.1 7-cyano-7-deazaguanine synthase QueC -
LQ335_RS16450 (LQ335_16450) 3565273..3565974 - 702 WP_111175715.1 7-carboxy-7-deazaguanine synthase QueE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10575.15 Da        Isoelectric Point: 9.6740

>T227003 WP_111175727.1 NZ_CP088244:c3561261-3560983 [Stenotrophomonas maltophilia]
MIRTYADKDTERIASGKKVKALANLEKQILRKLVYLNAATSLLDLKAPPGNRLEALKGDRSGQYSIRINDQFRICFKWKD
GDVYDVEITDYH

Download         Length: 279 bp

>T227003 NZ_CP122676:c4561777-4561604 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11192.94 Da        Isoelectric Point: 6.4602

>AT227003 WP_111175729.1 NZ_CP088244:c3560839-3560525 [Stenotrophomonas maltophilia]
MTRANAKTAIALPAIHPGEILSEEFLVPLGMSARALAAEINVTPARVSEIIAGRRGITADTALRLGRYFGTTPQLWLNLQ
TQYDLLTVSVELADVIDHISPRAA

Download         Length: 315 bp

>AT227003 NZ_CP122676:c4562101-4561805 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References