Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 112843..113431 Replicon chromosome
Accession NZ_CP088242
Organism Stenotrophomonas maltophilia strain 2013-SM13

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LQ330_RS00515 Protein ID WP_080355515.1
Coordinates 113153..113431 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8E3RGU6
Locus tag LQ330_RS00510 Protein ID WP_049439995.1
Coordinates 112843..113142 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ330_RS00490 (LQ330_00490) 108270..109457 + 1188 WP_130768214.1 pyridoxal phosphate-dependent aminotransferase -
LQ330_RS00495 (LQ330_00495) 109582..111678 - 2097 WP_064239222.1 prolyl oligopeptidase family serine peptidase -
LQ330_RS00500 (LQ330_00500) 111748..112071 - 324 WP_103282036.1 hypothetical protein -
LQ330_RS00505 (LQ330_00505) 112200..112802 + 603 WP_049464637.1 lipocalin family protein -
LQ330_RS00510 (LQ330_00510) 112843..113142 - 300 WP_049439995.1 HigA family addiction module antitoxin Antitoxin
LQ330_RS00515 (LQ330_00515) 113153..113431 - 279 WP_080355515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ330_RS00520 (LQ330_00520) 113638..114327 - 690 WP_103282037.1 methionine ABC transporter permease -
LQ330_RS00525 (LQ330_00525) 114324..115331 - 1008 WP_010481369.1 methionine ABC transporter ATP-binding protein -
LQ330_RS00530 (LQ330_00530) 115542..116438 - 897 WP_130768215.1 DMT family transporter -
LQ330_RS00535 (LQ330_00535) 116534..117016 + 483 WP_049464641.1 YajQ family cyclic di-GMP-binding protein -
LQ330_RS00540 (LQ330_00540) 117051..118148 - 1098 WP_049464643.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(27-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10682.19 Da        Isoelectric Point: 10.4115

>T227001 WP_080355515.1 NZ_CP088242:c113431-113153 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGACPRAWRPIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRRGQYSLRINDQWRLCFTWTD
SGADAVEIVDYH

Download         Length: 279 bp

>T227001 NZ_CP122676:c4334167-4333880 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10885.59 Da        Isoelectric Point: 11.3450

>AT227001 WP_049439995.1 NZ_CP088242:c113142-112843 [Stenotrophomonas maltophilia]
MKRPHNGMRAIHPGEILREEFLLPLSLSVNALAKALDVPATRLHAIVHGQRSISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRSEIERRVQPRAA

Download         Length: 300 bp

>AT227001 NZ_CP122676:c4333893-4333591 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References