Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 53..592 Replicon plasmid pEh60-3
Accession NZ_CP088224
Organism Enterobacter hormaechei strain Eh60

Toxin (Protein)


Gene name yafQ Uniprot ID A0A743XG04
Locus tag LK764_RS24310 Protein ID WP_001570851.1
Coordinates 317..592 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A5H6MLU0
Locus tag LK764_RS24305 Protein ID WP_001570852.1
Coordinates 53..313 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK764_RS24305 (LK764_24365) 53..313 + 261 WP_001570852.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LK764_RS24310 (LK764_24370) 317..592 + 276 WP_001570851.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
LK764_RS24315 (LK764_24375) 543..749 + 207 WP_162184628.1 hypothetical protein -
LK764_RS24320 (LK764_24380) 746..1408 - 663 WP_001570850.1 hypothetical protein -
LK764_RS24325 (LK764_24385) 1859..1996 + 138 Protein_5 ankyrin repeat domain-containing protein -
LK764_RS24330 (LK764_24390) 2280..2489 + 210 WP_001570848.1 hypothetical protein -
LK764_RS24335 (LK764_24395) 2486..2785 + 300 WP_075829807.1 hypothetical protein -
LK764_RS24340 (LK764_24400) 2782..3075 + 294 WP_045307798.1 hypothetical protein -
LK764_RS24345 (LK764_24405) 3151..3534 + 384 WP_152687291.1 hypothetical protein -
LK764_RS24350 (LK764_24410) 3527..3823 + 297 WP_045307796.1 hypothetical protein -
LK764_RS24355 (LK764_24415) 3813..4370 + 558 WP_049111304.1 type 4 pilus major pilin -
LK764_RS24360 (LK764_24420) 4386..4925 + 540 WP_045307794.1 type 4 pilus major pilin -
LK764_RS24365 (LK764_24425) 4942..5136 + 195 WP_048242338.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37406 37406


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10780.49 Da        Isoelectric Point: 9.6586

>T226982 WP_001570851.1 NZ_CP088224:317-592 [Enterobacter hormaechei]
MTTRMIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF

Download         Length: 276 bp

>T226982 NZ_CP122673:c4561780-4561607 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9239.63 Da        Isoelectric Point: 5.0336

>AT226982 WP_001570852.1 NZ_CP088224:53-313 [Enterobacter hormaechei]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI

Download         Length: 261 bp

>AT226982 NZ_CP122673:c4562104-4561808 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A743XG04

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6MLU0

References