Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2178243..2178745 | Replicon | chromosome |
| Accession | NC_010473 | ||
| Organism | Escherichia coli str. K-12 substr. DH10B | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | ECDH10B_RS11045 | Protein ID | WP_000767829.1 |
| Coordinates | 2178243..2178497 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | ECDH10B_RS11050 | Protein ID | WP_001259255.1 |
| Coordinates | 2178494..2178745 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECDH10B_RS11020 (ECDH10B_2159) | 2173258..2173485 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| ECDH10B_RS11025 (ECDH10B_2160) | 2173499..2174557 | - | 1059 | WP_000492339.1 | transport protein YeeE | - |
| ECDH10B_RS11030 (ECDH10B_2161) | 2174736..2176094 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| ECDH10B_RS26040 | 2176084..2176146 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| ECDH10B_RS11035 (ECDH10B_2162) | 2176361..2177290 | - | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
| ECDH10B_RS11040 (ECDH10B_2163) | 2177336..2178160 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| ECDH10B_RS11045 (ECDH10B_2164) | 2178243..2178497 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| ECDH10B_RS11050 (ECDH10B_2165) | 2178494..2178745 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| ECDH10B_RS24365 (ECDH10B_2166) | 2179028..2179078 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| ECDH10B_RS11055 (ECDH10B_2167) | 2179224..2180123 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| ECDH10B_RS11060 (ECDH10B_2168) | 2180129..2181433 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| ECDH10B_RS11065 (ECDH10B_2169) | 2181430..2182500 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| ECDH10B_RS11070 (ECDH10B_2170) | 2182500..2183567 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T22696 WP_000767829.1 NC_010473:c2178497-2178243 [Escherichia coli str. K-12 substr. DH10B]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T22696 NC_010473:c2178497-2178243 [Escherichia coli str. K-12 substr. DH10B]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT22696 WP_001259255.1 NC_010473:c2178745-2178494 [Escherichia coli str. K-12 substr. DH10B]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT22696 NC_010473:c2178745-2178494 [Escherichia coli str. K-12 substr. DH10B]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|