226956

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 58342..58861 Replicon chromosome
Accession NZ_CP088218
Organism Staphylococcus sp. HL28

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2V3ZBG9
Locus tag LPC11_RS00235 Protein ID WP_023374423.1
Coordinates 58589..58861 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2V3ZEN9
Locus tag LPC11_RS00230 Protein ID WP_023374424.1
Coordinates 58342..58596 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPC11_RS00215 (LPC11_00215) 53863..55185 + 1323 WP_023374427.1 PrsW family glutamic-type intramembrane protease -
LPC11_RS00220 (LPC11_00220) 55331..55768 + 438 WP_023374426.1 hypothetical protein -
LPC11_RS00225 (LPC11_00225) 55895..58096 - 2202 WP_023374425.1 YSIRK-type signal peptide-containing protein -
LPC11_RS00230 (LPC11_00230) 58342..58596 + 255 WP_023374424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LPC11_RS00235 (LPC11_00235) 58589..58861 + 273 WP_023374423.1 Txe/YoeB family addiction module toxin Toxin
LPC11_RS00240 (LPC11_00240) 59103..60473 + 1371 WP_023374422.1 citrate:proton symporter -
LPC11_RS00245 (LPC11_00245) 60566..61204 - 639 WP_023374421.1 NAD(P)H-dependent oxidoreductase -
LPC11_RS00250 (LPC11_00250) 61431..62297 - 867 WP_023374420.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10878.67 Da        Isoelectric Point: 10.1042

>T226956 WP_023374423.1 NZ_CP088218:58589-58861 [Staphylococcus sp. HL28]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINHFIKCINRNGPLQGEGKPEALKGNFKGYYSRRINFEHRLVYKVYDSSII
IVSCKYHYFK

Download         Length: 273 bp

>T226956 NZ_CP122661:c6246-6064 [Escherichia coli]
ATGAAATCTGCTGACCTGTTGAAAGAACTGATAGCTGCTGGTTGTGAGTTGAAGCGGCATAAGGCGAGCAGCCACCAGAT
ATGGTGGTCGCCCATAACAGGAAAAACTTTTCCTGTGCCCCATCCGAAAAAAGACTTGCCACTGGGTACTGTCAGATCGA
TCAGAAAAATGGCGGGGATTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9371.35 Da        Isoelectric Point: 4.0334

>AT226956 WP_023374424.1 NZ_CP088218:58342-58596 [Staphylococcus sp. HL28]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIEVDL
ELYE

Download         Length: 255 bp

>AT226956 NZ_CP122661:c6039-5602 [Escherichia coli]
ATGTTTTTTTCTGTGGGTGTCGAAACACCGAAAGATGACCATACGGCATATGGTATAACCGTTCCGGCTTTTGATCGTTT
TGATTTTGGCTGTGTCTCTGCTGCCGATACTCAATCAGAAATTCCTGTGATGGCGCGAGAAGCGATATTGGCTATCGTGG
AAGAAATGGTTTTAAGTGGTTCTTATTCTGTTGATGATATTCATGATGACGGCTGTTTAACATATGCCGCAAATCAGGAC
TATAGTCACTGCGATAGCTGGTTTGTAATTGATGTTGATTTGTCTGAAATTGAAGGTAAACAACAACGTATTAATATTGC
GTTGCCTGATGTGTTGATTCGTCGTATTGATGGATTTGTCAGAGAAAGTGGCGGTGTTTACAGAGATCGTAGCCATTTTC
TTGCTCAGGCCGCGCGGCATGAGCTTTCATATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZBG9

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3ZEN9

References