Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2773006..2773343 Replicon chromosome
Accession NZ_CP088200
Organism Enterococcus faecalis strain S39-4

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag LQ044_RS13680 Protein ID WP_002381035.1
Coordinates 2773006..2773149 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2773081..2773343 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ044_RS13660 2769107..2769736 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
LQ044_RS13665 2770429..2772045 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
LQ044_RS13670 2772375..2772518 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
LQ044_RS13675 2772637..2772777 + 141 WP_073340360.1 putative holin-like toxin -
LQ044_RS13680 2773006..2773149 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2773081..2773343 - 263 - - Antitoxin
LQ044_RS13685 2773344..2778035 - 4692 WP_010783624.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T226948 WP_002381035.1 NZ_CP088200:2773006-2773149 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T226948 NZ_CP122660:2654482-2654589 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 263 bp

>AT226948 NZ_CP088200:c2773343-2773081 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References