Detailed information of TA system TA226942

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2772637..2772908
• Replicon: chromosome
• Accession: NZ_CP088200
• Organism: Enterococcus faecalis strain S39-4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: LQ044_RS13675
• Protein ID: WP_073340360.1
• Coordinates: 2772637..2772777 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2772710..2772908 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ044_RS13655	2767851..2768843	+	993	WP_002354765.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LQ044_RS13660	2769107..2769736	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
LQ044_RS13665	2770429..2772045	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
LQ044_RS13670	2772375..2772518	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	-
LQ044_RS13675	2772637..2772777	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2772710..2772908	-	199	-	-	Antitoxin
LQ044_RS13680	2773006..2773149	+	144	WP_002381035.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T226942 WP_073340360.1 NZ_CP088200:2772637-2772777 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T226942 NZ_CP122660:1835752-1836003 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 199 bp

>AT226942 NZ_CP088200:c2772908-2772710 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATGGTAATGAAAAGAGAGCTATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin