Detailed information of TA system TA226930

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2686415..2686878
• Replicon: chromosome
• Accession: NZ_CP088200
• Organism: Enterococcus faecalis strain S39-4

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: LQ044_RS13270
• Protein ID: WP_002392696.1
• Coordinates: 2686415..2686558 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2686734..2686878 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ044_RS13255	2681661..2682374	-	714	WP_002381063.1	trehalose operon repressor	-
LQ044_RS13260	2682636..2685380	+	2745	WP_002398920.1	glycosyl hydrolase family 65 protein	-
LQ044_RS13265	2685395..2686045	+	651	WP_002354875.1	beta-phosphoglucomutase	-
LQ044_RS13270	2686415..2686558	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2686734..2686878	+	145	-	-	Antitoxin
LQ044_RS14735	2686966..2687091	-	126	WP_002398921.1	hypothetical protein	-
LQ044_RS13275	2687632..2687907	+	276	WP_224805966.1	CPBP family intramembrane metalloprotease	-
LQ044_RS13280	2687961..2688932	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LQ044_RS13285	2689107..2689544	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LQ044_RS13290	2689677..2690231	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T226930 WP_002392696.1 NZ_CP088200:c2686558-2686415 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T226930 NZ_CP122655:3622662-3622880 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 145 bp

>AT226930 NZ_CP088200:2686734-2686878 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin