Detailed information of TA system TA226917

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2622078..2622412
• Replicon: chromosome
• Accession: NZ_CP088198
• Organism: Enterococcus faecalis strain S11-6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ046_RS12270
• Protein ID: WP_002415596.1
• Coordinates: 2622078..2622221 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2622154..2622412 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ046_RS12250 (2617146)	2617146..2617361	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
LQ046_RS12255 (2617500)	2617500..2618492	+	993	WP_002358973.1	biotin--[acetyl-CoA-carboxylase] ligase	-
LQ046_RS12260 (2618796)	2618796..2619434	-	639	WP_002375448.1	lytic polysaccharide monooxygenase	-
LQ046_RS12265 (2620121)	2620121..2621737	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
LQ046_RS12270 (2622078)	2622078..2622221	+	144	WP_002415596.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2622154)	2622154..2622412	-	259	NuclAT_3	-	Antitoxin
- (2622363)	2622363..2622413	+	51	NuclAT_13	-	-
LQ046_RS12275 (2622414)	2622414..2626181	-	3768	WP_104807327.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5314.46 Da
• Isoelectric Point: 10.6323

>T226917 WP_002415596.1 NZ_CP088198:2622078-2622221 [Enterococcus faecalis]
MNVSAKIYERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T226917 NZ_CP122655:227315-227422 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 259 bp

>AT226917 NZ_CP088198:c2622412-2622154 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAA
TGATAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTACTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAA
GCAATGGTAAACATACCAA

Structures

Antitoxin