Detailed information of TA system TA226913

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2543633..2543904
• Replicon: chromosome
• Accession: NZ_CP088198
• Organism: Enterococcus faecalis strain S11-6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ046_RS11925
• Protein ID: WP_002375510.1
• Coordinates: 2543752..2543904 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2543633..2543819 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ046_RS11910 (2539600)	2539600..2542344	+	2745	WP_104807179.1	glycosyl hydrolase family 65 protein	-
LQ046_RS11915 (2542359)	2542359..2543009	+	651	WP_002375514.1	beta-phosphoglucomutase	-
- (2543078)	2543078..2543210	+	133	NuclAT_12	-	-
- (2543257)	2543257..2543444	+	188	NuclAT_4	-	-
LQ046_RS11920 (2543377)	2543377..2543481	-	105	WP_023894767.1	putative holin-like toxin	-
- (2543633)	2543633..2543778	+	146	NuclAT_11	-	-
- (2543633)	2543633..2543819	+	187	NuclAT_5	-	Antitoxin
LQ046_RS11925 (2543752)	2543752..2543904	-	153	WP_002375510.1	type I toxin-antitoxin system toxin PepG1	Toxin
LQ046_RS11930 (2544129)	2544129..2545100	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LQ046_RS11935 (2545275)	2545275..2545712	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LQ046_RS11940 (2545845)	2545845..2546399	-	555	WP_002354869.1	Maf family protein	-
LQ046_RS11945 (2546424)	2546424..2548556	-	2133	WP_002375508.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5637.90 Da
• Isoelectric Point: 11.0942

>T226913 WP_002375510.1 NZ_CP088198:c2543904-2543752 [Enterococcus faecalis]
VVRMSALPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 153 bp

>T226913 NZ_CP122652:c4819594-4819283 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 187 bp

>AT226913 NZ_CP088198:2543633-2543819 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin