Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2464736..2464960 Replicon chromosome
Accession NZ_CP088198
Organism Enterococcus faecalis strain S11-6

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag LQ046_RS11555 Protein ID WP_162780856.1
Coordinates 2464859..2464960 (-) Length 34 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2464736..2464922 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ046_RS11530 (2460354) 2460354..2461307 - 954 WP_002375576.1 siderophore ABC transporter substrate-binding protein -
LQ046_RS11535 (2461346) 2461346..2462101 - 756 WP_002375575.1 ATP-binding cassette domain-containing protein -
LQ046_RS11540 (2462098) 2462098..2463063 - 966 WP_002371665.1 iron chelate uptake ABC transporter family permease subunit -
LQ046_RS11545 (2463060) 2463060..2464007 - 948 WP_002375573.1 iron chelate uptake ABC transporter family permease subunit -
LQ046_RS11550 (2464191) 2464191..2464643 + 453 WP_002375572.1 YueI family protein -
- (2464699) 2464699..2464905 + 207 NuclAT_7 - -
- (2464736) 2464736..2464922 + 187 NuclAT_9 - Antitoxin
LQ046_RS11555 (2464859) 2464859..2464960 - 102 WP_162780856.1 putative holin-like toxin Toxin
LQ046_RS11560 (2465152) 2465152..2467422 - 2271 WP_002368430.1 bifunctional glutamate--cysteine ligase/glutathione synthetase -
LQ046_RS11565 (2467593) 2467593..2468093 + 501 WP_002395960.1 cysteine hydrolase family protein -
LQ046_RS11570 (2468892) 2468892..2469788 + 897 WP_002368434.1 YitT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(1-33)


Sequences

Toxin        


Download         Length: 34 a.a.        Molecular weight: 3624.40 Da        Isoelectric Point: 6.0656

>T226905 WP_162780856.1 NZ_CP088198:c2464960-2464859 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Download         Length: 102 bp

>T226905 NZ_CP122652:2904824-2904931 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 187 bp

>AT226905 NZ_CP088198:2464736-2464922 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References