Detailed information of TA system TA226902

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2464699..2464960
• Replicon: chromosome
• Accession: NZ_CP088198
• Organism: Enterococcus faecalis strain S11-6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LQ046_RS11555
• Protein ID: WP_162780856.1
• Coordinates: 2464859..2464960 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2464699..2464905 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ046_RS11530 (2460354)	2460354..2461307	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
LQ046_RS11535 (2461346)	2461346..2462101	-	756	WP_002375575.1	ATP-binding cassette domain-containing protein	-
LQ046_RS11540 (2462098)	2462098..2463063	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
LQ046_RS11545 (2463060)	2463060..2464007	-	948	WP_002375573.1	iron chelate uptake ABC transporter family permease subunit	-
LQ046_RS11550 (2464191)	2464191..2464643	+	453	WP_002375572.1	YueI family protein	-
- (2464699)	2464699..2464905	+	207	NuclAT_7	-	Antitoxin
- (2464736)	2464736..2464922	+	187	NuclAT_9	-	-
LQ046_RS11555 (2464859)	2464859..2464960	-	102	WP_162780856.1	putative holin-like toxin	Toxin
LQ046_RS11560 (2465152)	2465152..2467422	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LQ046_RS11565 (2467593)	2467593..2468093	+	501	WP_002395960.1	cysteine hydrolase family protein	-
LQ046_RS11570 (2468892)	2468892..2469788	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T226902 WP_162780856.1 NZ_CP088198:c2464960-2464859 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T226902 NZ_CP122652:2481780-2482067 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 207 bp

>AT226902 NZ_CP088198:2464699-2464905 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATGAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGG
TTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin