Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2422731..2423248 | Replicon | chromosome |
| Accession | NZ_CP088158 | ||
| Organism | Staphylococcus aureus strain 697 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | LRP64_RS11950 | Protein ID | WP_000113263.1 |
| Coordinates | 2422731..2422997 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | LRP64_RS11955 | Protein ID | WP_000584499.1 |
| Coordinates | 2422997..2423248 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRP64_RS11920 (2417991) | 2417991..2418527 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| LRP64_RS11925 (2418940) | 2418940..2419764 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| LRP64_RS11930 (2419968) | 2419968..2420150 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| LRP64_RS11935 (2420237) | 2420237..2420704 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| LRP64_RS11940 (2420890) | 2420890..2422437 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| LRP64_RS11945 (2422625) | 2422625..2422696 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| LRP64_RS11950 (2422731) | 2422731..2422997 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| LRP64_RS11955 (2422997) | 2422997..2423248 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LRP64_RS11960 (2423421) | 2423421..2423512 | - | 92 | Protein_2310 | hypothetical protein | - |
| LRP64_RS11965 (2423519) | 2423519..2424118 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| LRP64_RS11970 (2424137) | 2424137..2424499 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| LRP64_RS11975 (2424754) | 2424754..2426004 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| LRP64_RS11980 (2426101) | 2426101..2426832 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| LRP64_RS11985 (2426829) | 2426829..2427548 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T226890 WP_000113263.1 NZ_CP088158:c2422997-2422731 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T226890 NZ_CP122648:c4623942-4623769 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT226890 WP_000584499.1 NZ_CP088158:c2423248-2422997 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT226890 NZ_CP122648:c4624266-4623970 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGATTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|