Detailed information of TA system TA226888

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2160618..2160835
• Replicon: chromosome
• Accession: NZ_CP088158
• Organism: Staphylococcus aureus strain 697

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LRP64_RS10595
• Protein ID: WP_001802298.1
• Coordinates: 2160731..2160835 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2160618..2160673 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRP64_RS10570	2156809..2157474	-	666	WP_001024088.1	SDR family oxidoreductase	-
LRP64_RS10575	2157626..2157946	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LRP64_RS10580	2157948..2158925	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
LRP64_RS10585	2159191..2160282	+	1092	WP_000495695.1	hypothetical protein	-
-	2160618..2160673	+	56	-	-	Antitoxin
LRP64_RS10595	2160731..2160835	-	105	WP_001802298.1	hypothetical protein	Toxin
LRP64_RS10600	2160996..2161479	-	484	Protein_2048	recombinase family protein	-
LRP64_RS10605	2161522..2162658	-	1137	Protein_2049	SAP domain-containing protein	-
LRP64_RS10610	2162947..2163039	+	93	WP_031844941.1	hypothetical protein	-
LRP64_RS10620	2163734..2164591	-	858	WP_000370919.1	HAD family hydrolase	-
LRP64_RS10625	2164659..2165441	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T226888 WP_001802298.1 NZ_CP088158:c2160835-2160731 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T226888 NZ_CP122648:c4395736-4395449 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT226888 NZ_CP088158:2160618-2160673 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin