Detailed information of TA system TA226883

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1860833..1861132
• Replicon: chromosome
• Accession: NZ_CP088158
• Organism: Staphylococcus aureus strain 697

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LRP64_RS08830
• Protein ID: WP_011447039.1
• Coordinates: 1860956..1861132 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1860833..1860888 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRP64_RS08790	1856164..1856424	+	261	WP_001791826.1	hypothetical protein	-
LRP64_RS08795	1856477..1856827	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
LRP64_RS08800	1857512..1857961	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
LRP64_RS08805	1858056..1858391	-	336	Protein_1732	SH3 domain-containing protein	-
LRP64_RS08810	1859041..1859532	-	492	WP_000919350.1	staphylokinase	-
LRP64_RS08815	1859723..1860478	-	756	WP_000861038.1	CHAP domain-containing protein	-
LRP64_RS08820	1860490..1860744	-	255	WP_000611512.1	phage holin	-
LRP64_RS08825	1860796..1860903	+	108	WP_001791821.1	hypothetical protein	-
-	1860825..1860964	+	140	NuclAT_0	-	-
-	1860825..1860964	+	140	NuclAT_0	-	-
-	1860825..1860964	+	140	NuclAT_0	-	-
-	1860825..1860964	+	140	NuclAT_0	-	-
-	1860833..1860888	+	56	-	-	Antitoxin
LRP64_RS08830	1860956..1861132	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
LRP64_RS08835	1861282..1861578	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
LRP64_RS08840	1861636..1861923	-	288	WP_001040261.1	hypothetical protein	-
LRP64_RS08845	1861970..1862122	-	153	WP_001153681.1	hypothetical protein	-
LRP64_RS08850	1862112..1865897	-	3786	WP_044557000.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / scn / chp / sak	1843812..1904140	60328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T226883 WP_011447039.1 NZ_CP088158:c1861132-1860956 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T226883 NZ_CP122648:c3078376-3077999 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATAACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT226883 NZ_CP088158:1860833-1860888 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin