Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprG3-sprA1AS/-
Location 2242067..2242264 Replicon chromosome
Accession NZ_CP088157
Organism Staphylococcus aureus strain 199

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag LQK05_RS11335 Protein ID WP_001802298.1
Coordinates 2242160..2242264 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 2242067..2242105 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQK05_RS11310 2238254..2238919 - 666 WP_001024089.1 SDR family oxidoreductase -
LQK05_RS11315 2239071..2239391 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
LQK05_RS11320 2239393..2240370 + 978 WP_000019733.1 CDF family zinc efflux transporter CzrB -
LQK05_RS11325 2240636..2241727 + 1092 WP_000495669.1 hypothetical protein -
LQK05_RS11330 2242047..2242121 + 75 Protein_2199 hypothetical protein -
- 2242067..2242105 + 39 - - Antitoxin
LQK05_RS11335 2242160..2242264 - 105 WP_001802298.1 hypothetical protein Toxin
LQK05_RS11340 2242944..2243102 + 159 WP_001792784.1 hypothetical protein -
LQK05_RS11345 2243760..2244617 - 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
LQK05_RS11350 2244685..2245467 - 783 WP_000908185.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T226876 WP_001802298.1 NZ_CP088157:c2242264-2242160 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T226876 NZ_CP122648:2027999-2028253 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 39 bp

>AT226876 NZ_CP088157:2242067-2242105 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References