Detailed information of TA system TA226874

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2242048..2242264
• Replicon: chromosome
• Accession: NZ_CP088157
• Organism: Staphylococcus aureus strain 199

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LQK05_RS11335
• Protein ID: WP_001802298.1
• Coordinates: 2242160..2242264 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2242048..2242103 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQK05_RS11310	2238254..2238919	-	666	WP_001024089.1	SDR family oxidoreductase	-
LQK05_RS11315	2239071..2239391	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LQK05_RS11320	2239393..2240370	+	978	WP_000019733.1	CDF family zinc efflux transporter CzrB	-
LQK05_RS11325	2240636..2241727	+	1092	WP_000495669.1	hypothetical protein	-
-	2242048..2242103	+	56	-	-	Antitoxin
LQK05_RS11335	2242160..2242264	-	105	WP_001802298.1	hypothetical protein	Toxin
LQK05_RS11340	2242944..2243102	+	159	WP_001792784.1	hypothetical protein	-
LQK05_RS11345	2243760..2244617	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
LQK05_RS11350	2244685..2245467	-	783	WP_000908185.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T226874 WP_001802298.1 NZ_CP088157:c2242264-2242160 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T226874 NZ_CP122648:1157423-1157734 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAATAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT226874 NZ_CP088157:2242048-2242103 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin