Detailed information of TA system TA226869

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2057819..2058126
• Replicon: chromosome
• Accession: NZ_CP088157
• Organism: Staphylococcus aureus strain 199

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LQK05_RS10285
• Protein ID: WP_011447039.1
• Coordinates: 2057950..2058126 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2057819..2057958 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQK05_RS10245 (2053160)	2053160..2053420	+	261	WP_001791826.1	hypothetical protein	-
LQK05_RS10250 (2053473)	2053473..2053823	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
LQK05_RS10255 (2054506)	2054506..2054955	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
LQK05_RS10260 (2055050)	2055050..2055384	-	335	Protein_1989	SH3 domain-containing protein	-
LQK05_RS10265 (2056035)	2056035..2056526	-	492	WP_000920042.1	staphylokinase	-
LQK05_RS10270 (2056717)	2056717..2057472	-	756	WP_000861026.1	CHAP domain-containing protein	-
LQK05_RS10275 (2057484)	2057484..2057738	-	255	WP_000611512.1	phage holin	-
LQK05_RS10280 (2057790)	2057790..2057897	+	108	WP_031762631.1	hypothetical protein	-
- (2057819)	2057819..2057958	+	140	NuclAT_0	-	Antitoxin
- (2057819)	2057819..2057958	+	140	NuclAT_0	-	Antitoxin
- (2057819)	2057819..2057958	+	140	NuclAT_0	-	Antitoxin
- (2057819)	2057819..2057958	+	140	NuclAT_0	-	Antitoxin
LQK05_RS10285 (2057950)	2057950..2058126	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
LQK05_RS10290 (2058329)	2058329..2059111	-	783	WP_000034846.1	staphylococcal enterotoxin type P	-
LQK05_RS10295 (2059518)	2059518..2059892	-	375	WP_000340977.1	hypothetical protein	-
LQK05_RS10300 (2059948)	2059948..2060235	-	288	WP_031865201.1	hypothetical protein	-
LQK05_RS10305 (2060281)	2060281..2060433	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / see / hlb / groEL	2053473..2119329	65856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T226869 WP_011447039.1 NZ_CP088157:c2058126-2057950 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T226869 NZ_CP122643:c4947097-4946786 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT226869 NZ_CP088157:2057819-2057958 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin