Detailed information of TA system TA226864

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1579949..1580528
• Replicon: chromosome
• Accession: NZ_CP088157
• Organism: Staphylococcus aureus strain 199

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: LQK05_RS07700
• Protein ID: WP_001025401.1
• Coordinates: 1580283..1580528 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1579949..1580314 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQK05_RS07660 (1576693)	1576693..1577250	-	558	WP_000645042.1	DUF2815 family protein	-
LQK05_RS07665 (1577276)	1577276..1578442	-	1167	WP_000762532.1	DUF2800 domain-containing protein	-
LQK05_RS07670 (1578439)	1578439..1578801	-	363	WP_000279445.1	hypothetical protein	-
LQK05_RS07675 (1578816)	1578816..1579139	-	324	WP_000174995.1	hypothetical protein	-
LQK05_RS07680 (1579218)	1579218..1579379	-	162	WP_015986189.1	DUF1270 family protein	-
LQK05_RS07685 (1579391)	1579391..1579654	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
LQK05_RS07690 (1579679)	1579679..1579894	-	216	WP_001097552.1	hypothetical protein	-
LQK05_RS07695 (1579949)	1579949..1580314	+	366	WP_001128433.1	hypothetical protein	Antitoxin
LQK05_RS07700 (1580283)	1580283..1580528	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
LQK05_RS07705 (1580557)	1580557..1581333	-	777	WP_072519170.1	Rha family transcriptional regulator	-
LQK05_RS07710 (1581347)	1581347..1581583	-	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
LQK05_RS07715 (1581735)	1581735..1582049	+	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
LQK05_RS07720 (1582062)	1582062..1582523	+	462	WP_072519171.1	toxin	-
LQK05_RS07725 (1582540)	1582540..1583124	+	585	WP_072519172.1	hypothetical protein	-
LQK05_RS07730 (1583354)	1583354..1583500	+	147	WP_001013104.1	hypothetical protein	-
LQK05_RS07735 (1583497)	1583497..1584111	-	615	WP_000191457.1	hypothetical protein	-
LQK05_RS07740 (1584237)	1584237..1585442	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV / gnd	1535872..1609817	73945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T226864 WP_001025401.1 NZ_CP088157:c1580528-1580283 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T226864 NZ_CP122643:c4031335-4030937 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT226864 NZ_CP088157:1579949-1580314 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin