Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4474699..4475453 | Replicon | chromosome |
| Accession | NZ_CP088142 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | LRM93_RS21665 | Protein ID | WP_000558168.1 |
| Coordinates | 4474699..4475010 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRM93_RS21670 | Protein ID | WP_001259009.1 |
| Coordinates | 4475007..4475453 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM93_RS21635 (4470357) | 4470357..4471259 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| LRM93_RS21640 (4471256) | 4471256..4471891 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LRM93_RS21645 (4471888) | 4471888..4472817 | + | 930 | WP_000027737.1 | formate dehydrogenase accessory protein FdhE | - |
| LRM93_RS21650 (4472864) | 4472864..4473154 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LRM93_RS21655 (4473155) | 4473155..4473466 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LRM93_RS21660 (4473684) | 4473684..4474613 | + | 930 | WP_001127705.1 | alpha/beta hydrolase | - |
| LRM93_RS21665 (4474699) | 4474699..4475010 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LRM93_RS21670 (4475007) | 4475007..4475453 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LRM93_RS21675 (4475468) | 4475468..4476409 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LRM93_RS21680 (4476454) | 4476454..4476891 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| LRM93_RS21685 (4476888) | 4476888..4477760 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LRM93_RS21690 (4477754) | 4477754..4478353 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LRM93_RS21695 (4478544) | 4478544..4479347 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LRM93_RS21700 (4479381) | 4479381..4480277 | - | 897 | WP_001697015.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T226836 WP_000558168.1 NZ_CP088142:4474699-4475010 [Salmonella enterica subsp. enterica serovar Gallinarum]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T226836 NZ_CP122634:4207815-4208093 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT226836 WP_001259009.1 NZ_CP088142:4475007-4475453 [Salmonella enterica subsp. enterica serovar Gallinarum]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT226836 NZ_CP122634:4207552-4207812 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|