Detailed information of TA system TA226835

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4472864..4473466
• Replicon: chromosome
• Accession: NZ_CP088142
• Organism: Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4548

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LRM93_RS21655
• Protein ID: WP_001159635.1
• Coordinates: 4473155..4473466 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LRM93_RS21650
• Protein ID: WP_000362050.1
• Coordinates: 4472864..4473154 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM93_RS21635 (4470357)	4470357..4471259	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LRM93_RS21640 (4471256)	4471256..4471891	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LRM93_RS21645 (4471888)	4471888..4472817	+	930	WP_000027737.1	formate dehydrogenase accessory protein FdhE	-
LRM93_RS21650 (4472864)	4472864..4473154	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LRM93_RS21655 (4473155)	4473155..4473466	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LRM93_RS21660 (4473684)	4473684..4474613	+	930	WP_001127705.1	alpha/beta hydrolase	-
LRM93_RS21665 (4474699)	4474699..4475010	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LRM93_RS21670 (4475007)	4475007..4475453	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LRM93_RS21675 (4475468)	4475468..4476409	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LRM93_RS21680 (4476454)	4476454..4476891	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LRM93_RS21685 (4476888)	4476888..4477760	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LRM93_RS21690 (4477754)	4477754..4478353	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T226835 WP_001159635.1 NZ_CP088142:c4473466-4473155 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T226835 NZ_CP122634:c4201753-4201355 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGCTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT226835 WP_000362050.1 NZ_CP088142:c4473154-4472864 [Salmonella enterica subsp. enterica serovar Gallinarum]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT226835 NZ_CP122634:c4202049-4201756 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97