Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4700745..4701499 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LRM92_RS22935 Protein ID WP_000558166.1
Coordinates 4700745..4701056 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LRM92_RS22940 Protein ID WP_001259011.1
Coordinates 4701053..4701499 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS22905 (4696403) 4696403..4697305 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LRM92_RS22910 (4697302) 4697302..4697937 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LRM92_RS22915 (4697934) 4697934..4698863 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LRM92_RS22920 (4698910) 4698910..4699200 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LRM92_RS22925 (4699201) 4699201..4699512 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LRM92_RS22930 (4699730) 4699730..4700659 + 930 WP_001127703.1 alpha/beta hydrolase -
LRM92_RS22935 (4700745) 4700745..4701056 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LRM92_RS22940 (4701053) 4701053..4701499 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LRM92_RS22945 (4701514) 4701514..4702455 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LRM92_RS22950 (4702500) 4702500..4702937 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LRM92_RS22955 (4702934) 4702934..4703806 - 873 WP_000921427.1 virulence factor BrkB family protein -
LRM92_RS22960 (4703800) 4703800..4704399 - 600 WP_000965695.1 glucose-1-phosphatase -
LRM92_RS22965 (4704590) 4704590..4705393 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LRM92_RS22970 (4705427) 4705427..4706323 - 897 WP_001520529.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T226811 WP_000558166.1 NZ_CP088138:4700745-4701056 [Salmonella enterica subsp. enterica serovar Hissar]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T226811 NZ_CP122629:c4780636-4780325 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT226811 WP_001259011.1 NZ_CP088138:4701053-4701499 [Salmonella enterica subsp. enterica serovar Hissar]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT226811 NZ_CP122629:c4780324-4780034 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References