Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2460025..2460547 Replicon chromosome
Accession NZ_CP088138
Organism Salmonella enterica subsp. enterica serovar Hissar strain SCPM-O-B-4549

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LRM92_RS12050 Protein ID WP_000221343.1
Coordinates 2460263..2460547 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LRM92_RS12045 Protein ID WP_000885424.1
Coordinates 2460025..2460273 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM92_RS12020 (2455241) 2455241..2456707 + 1467 WP_000987828.1 hypothetical protein -
LRM92_RS12025 (2457515) 2457515..2458229 + 715 Protein_2358 helix-turn-helix domain-containing protein -
LRM92_RS12030 (2458285) 2458285..2459193 - 909 WP_010989018.1 hypothetical protein -
LRM92_RS12035 (2459336) 2459336..2459668 - 333 WP_000253154.1 DUF1493 family protein -
LRM92_RS12040 (2459658) 2459658..2459873 - 216 WP_000206207.1 hypothetical protein -
LRM92_RS12045 (2460025) 2460025..2460273 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LRM92_RS12050 (2460263) 2460263..2460547 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LRM92_RS12055 (2460718) 2460718..2461107 + 390 WP_000194089.1 RidA family protein -
LRM92_RS12060 (2461240) 2461240..2461608 - 369 Protein_2365 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LRM92_RS12065 (2461801) 2461801..2462289 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
LRM92_RS12070 (2462334) 2462334..2463839 + 1506 WP_156038052.1 FAD-dependent oxidoreductase -
LRM92_RS12075 (2463829) 2463829..2465070 + 1242 WP_156038051.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2455244..2466696 11452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T226802 WP_000221343.1 NZ_CP088138:2460263-2460547 [Salmonella enterica subsp. enterica serovar Hissar]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T226802 NZ_CP122629:2802746-2802853 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT226802 WP_000885424.1 NZ_CP088138:2460025-2460273 [Salmonella enterica subsp. enterica serovar Hissar]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT226802 NZ_CP122629:c2802698-2802631 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References