Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4462937..4463691 | Replicon | chromosome |
| Accession | NZ_CP088136 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | LRM91_RS21520 | Protein ID | WP_000558168.1 |
| Coordinates | 4462937..4463248 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRM91_RS21525 | Protein ID | WP_001259009.1 |
| Coordinates | 4463245..4463691 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM91_RS21490 (4458595) | 4458595..4459497 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| LRM91_RS21495 (4459494) | 4459494..4460129 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LRM91_RS21500 (4460126) | 4460126..4461055 | + | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
| LRM91_RS21505 (4461102) | 4461102..4461392 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LRM91_RS21510 (4461393) | 4461393..4461704 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LRM91_RS21515 (4461922) | 4461922..4462851 | + | 930 | WP_000171444.1 | alpha/beta hydrolase | - |
| LRM91_RS21520 (4462937) | 4462937..4463248 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LRM91_RS21525 (4463245) | 4463245..4463691 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LRM91_RS21530 (4463706) | 4463706..4464647 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LRM91_RS21535 (4464692) | 4464692..4465129 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| LRM91_RS21540 (4465126) | 4465126..4465998 | - | 873 | WP_249895296.1 | virulence factor BrkB family protein | - |
| LRM91_RS21545 (4465992) | 4465992..4466591 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LRM91_RS21550 (4466782) | 4466782..4467585 | - | 804 | WP_249895297.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LRM91_RS21555 (4467619) | 4467619..4468515 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T226785 WP_000558168.1 NZ_CP088136:4462937-4463248 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T226785 NZ_CP122625:3713766-3714044 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT226785 WP_001259009.1 NZ_CP088136:4463245-4463691 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT226785 NZ_CP122625:3713503-3713763 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|