Detailed information of TA system TA226784

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4461102..4461704
• Replicon: chromosome
• Accession: NZ_CP088136
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LRM91_RS21510
• Protein ID: WP_001159635.1
• Coordinates: 4461393..4461704 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LRM91_RS21505
• Protein ID: WP_000362050.1
• Coordinates: 4461102..4461392 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM91_RS21490 (4458595)	4458595..4459497	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LRM91_RS21495 (4459494)	4459494..4460129	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LRM91_RS21500 (4460126)	4460126..4461055	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LRM91_RS21505 (4461102)	4461102..4461392	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LRM91_RS21510 (4461393)	4461393..4461704	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LRM91_RS21515 (4461922)	4461922..4462851	+	930	WP_000171444.1	alpha/beta hydrolase	-
LRM91_RS21520 (4462937)	4462937..4463248	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LRM91_RS21525 (4463245)	4463245..4463691	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LRM91_RS21530 (4463706)	4463706..4464647	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LRM91_RS21535 (4464692)	4464692..4465129	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LRM91_RS21540 (4465126)	4465126..4465998	-	873	WP_249895296.1	virulence factor BrkB family protein	-
LRM91_RS21545 (4465992)	4465992..4466591	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T226784 WP_001159635.1 NZ_CP088136:c4461704-4461393 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T226784 NZ_CP122625:3512722-3512940 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT226784 WP_000362050.1 NZ_CP088136:c4461392-4461102 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT226784 NZ_CP122625:3512322-3512696 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A3V2JK97