Detailed information of TA system TA226746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 1961335..1961937
• Replicon: chromosome
• Accession: NZ_CP088134
• Organism: Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: LRM90_RS09535
• Protein ID: WP_001159630.1
• Coordinates: 1961626..1961937 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LRM90_RS09530
• Protein ID: WP_000362050.1
• Coordinates: 1961335..1961625 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM90_RS09515 (1958828)	1958828..1959730	+	903	WP_001541228.1	formate dehydrogenase subunit beta	-
LRM90_RS09520 (1959727)	1959727..1960362	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LRM90_RS09525 (1960359)	1960359..1961288	+	930	WP_001541226.1	formate dehydrogenase accessory protein FdhE	-
LRM90_RS09530 (1961335)	1961335..1961625	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LRM90_RS09535 (1961626)	1961626..1961937	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LRM90_RS09540 (1962155)	1962155..1963070	+	916	Protein_1858	alpha/beta hydrolase	-
LRM90_RS09545 (1963084)	1963084..1964025	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LRM90_RS09550 (1964070)	1964070..1964507	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
LRM90_RS09555 (1964504)	1964504..1965376	-	873	WP_023235429.1	virulence factor BrkB family protein	-
LRM90_RS09560 (1965370)	1965370..1965969	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T226746 WP_001159630.1 NZ_CP088134:c1961937-1961626 [Salmonella enterica subsp. enterica serovar Gallinarum]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T226746 NZ_CP122620:1961828-1962079 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT226746 WP_000362050.1 NZ_CP088134:c1961625-1961335 [Salmonella enterica subsp. enterica serovar Gallinarum]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT226746 NZ_CP122620:1962076-1962330 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64