Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 32773..33301 | Replicon | chromosome |
| Accession | NZ_CP088134 | ||
| Organism | Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LRM90_RS00205 | Protein ID | WP_108429764.1 |
| Coordinates | 32773..33003 (+) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LRM90_RS00210 | Protein ID | WP_000147078.1 |
| Coordinates | 32993..33301 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM90_RS00170 (28600) | 28600..28989 | - | 390 | WP_001539749.1 | RusA family crossover junction endodeoxyribonuclease | - |
| LRM90_RS00175 (28986) | 28986..29639 | - | 654 | WP_001539748.1 | phage N-6-adenine-methyltransferase | - |
| LRM90_RS00180 (29639) | 29639..30121 | - | 483 | WP_023234881.1 | PerC family transcriptional regulator | - |
| LRM90_RS00185 (30123) | 30123..30941 | - | 819 | WP_001539747.1 | helix-turn-helix domain-containing protein | - |
| LRM90_RS00190 (30938) | 30938..31162 | - | 225 | WP_000620702.1 | hypothetical protein | - |
| LRM90_RS00195 (31159) | 31159..31896 | - | 738 | Protein_38 | Rha family transcriptional regulator | - |
| LRM90_RS00200 (32020) | 32020..32649 | - | 630 | Protein_39 | Rha family transcriptional regulator | - |
| LRM90_RS00205 (32773) | 32773..33003 | + | 231 | WP_108429764.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LRM90_RS00210 (32993) | 32993..33301 | + | 309 | WP_000147078.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LRM90_RS00215 (33320) | 33320..33496 | - | 177 | WP_001525520.1 | DUF4222 domain-containing protein | - |
| LRM90_RS00220 (33636) | 33636..34190 | - | 555 | WP_000509731.1 | YmfL family putative regulatory protein | - |
| LRM90_RS00225 (34219) | 34219..34443 | - | 225 | WP_001191666.1 | helix-turn-helix transcriptional regulator | - |
| LRM90_RS00230 (34541) | 34541..35236 | + | 696 | WP_001020640.1 | helix-turn-helix transcriptional regulator | - |
| LRM90_RS00235 (35571) | 35571..35768 | - | 198 | WP_001624554.1 | hypothetical protein | - |
| LRM90_RS00240 (36326) | 36326..36682 | + | 357 | WP_001539742.1 | hypothetical protein | - |
| LRM90_RS00245 (36740) | 36740..37567 | + | 828 | WP_023234876.1 | DUF2303 family protein | - |
| LRM90_RS00250 (37704) | 37704..37862 | + | 159 | WP_000008355.1 | hypothetical protein | - |
| LRM90_RS00255 (37931) | 37931..38176 | + | 246 | WP_000939947.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1813..40646 | 38833 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8640.11 Da Isoelectric Point: 10.5308
>T226740 WP_108429764.1 NZ_CP088134:32773-33003 [Salmonella enterica subsp. enterica serovar Gallinarum]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLAGKRIVMLHSFIKKTQKTPVAERKKAETRMKEVKHDW
Download Length: 231 bp
>T226740 NZ_CP122620:c612597-612133 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11110.77 Da Isoelectric Point: 7.0152
>AT226740 WP_000147078.1 NZ_CP088134:32993-33301 [Salmonella enterica subsp. enterica serovar Gallinarum]
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
MTGKRNAPTITHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLAAGVSG
PSFTTLKKFAQATGKKLQIRFV
Download Length: 309 bp
>AT226740 NZ_CP122620:c612932-612597 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|