Detailed information of TA system TA022673

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4072254..4072666
• Replicon: chromosome
• Accession: NC_010468
• Organism: Escherichia coli ATCC 8739

Toxin (Protein)

• Gene name: symE
• Uniprot ID: B1IS82
• Locus tag: ECOLC_RS19995
• Protein ID: WP_000132625.1
• Coordinates: 4072325..4072666 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4072254..4072330 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECOLC_RS19985	4069685..4070347	+	663	Protein_3806	N-6 DNA methylase	-
ECOLC_RS19990	4070347..4072104	+	1758	WP_000110077.1	restriction endonuclease subunit S	-
-	4072254..4072330	-	77	NuclAT_12	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_12	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_12	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_12	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_13	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_13	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_13	-	Antitoxin
-	4072254..4072330	-	77	NuclAT_13	-	Antitoxin
ECOLC_RS19995	4072325..4072666	+	342	WP_000132625.1	endoribonuclease SymE	Toxin
ECOLC_RS20000	4072713..4074806	-	2094	WP_000648226.1	DUF262 domain-containing protein	-
ECOLC_RS20005	4074903..4075067	-	165	WP_000394276.1	DUF1127 domain-containing protein	-
ECOLC_RS20010	4075244..4076656	+	1413	WP_000199353.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12270.10 Da
• Isoelectric Point: 8.4952

>T22673 WP_000132625.1 NC_010468:4072325-4072666 [Escherichia coli ATCC 8739]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVVVKVMEGCIVLTAQPAAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T22673 NC_010468:4072325-4072666 [Escherichia coli ATCC 8739]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGTTGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCCGCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTGATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT22673 NC_010468:c4072330-4072254 [Escherichia coli ATCC 8739]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: B1IS82

Antitoxin