Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 727121..727814 Replicon chromosome
Accession NZ_CP088131
Organism Escherichia coli strain 81

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LRM32_RS03600 Protein ID WP_000415584.1
Coordinates 727121..727417 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LRM32_RS03605 Protein ID WP_000650107.1
Coordinates 727419..727814 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM32_RS03565 (722210) 722210..722524 - 315 WP_000958598.1 putative quinol monooxygenase -
LRM32_RS03570 (722555) 722555..723136 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LRM32_RS03575 (723455) 723455..723787 + 333 WP_000917684.1 DUF2645 family protein -
LRM32_RS03580 (723833) 723833..725182 - 1350 WP_060618027.1 quorum sensing histidine kinase QseC -
LRM32_RS03585 (725179) 725179..725838 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LRM32_RS03590 (725989) 725989..726381 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LRM32_RS03595 (726434) 726434..726916 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LRM32_RS03600 (727121) 727121..727417 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LRM32_RS03605 (727419) 727419..727814 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LRM32_RS03610 (727947) 727947..729554 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LRM32_RS03615 (729692) 729692..731950 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T226719 WP_000415584.1 NZ_CP088131:727121-727417 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T226719 NZ_CP122617:858412-858819 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT226719 WP_000650107.1 NZ_CP088131:727419-727814 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT226719 NZ_CP122617:858165-858431 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References