22671

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3712850..3713391 Replicon chromosome
Accession NC_010468
Organism Escherichia coli ATCC 8739

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag ECOLC_RS18225 Protein ID WP_000615979.1
Coordinates 3713113..3713391 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag ECOLC_RS18220 Protein ID WP_000729704.1
Coordinates 3712850..3713110 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLC_RS18205 3708909..3711002 + 2094 WP_001140809.1 flagellar biosynthesis protein FlhA -
ECOLC_RS18210 3711218..3711715 - 498 WP_000006261.1 REP-associated tyrosine transposase RayT -
ECOLC_RS18215 3711891..3712664 - 774 WP_001353765.1 C40 family peptidase -
ECOLC_RS18220 3712850..3713110 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ECOLC_RS18225 3713113..3713391 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ECOLC_RS18230 3713547..3714287 + 741 WP_001225679.1 murein L,D-transpeptidase -
ECOLC_RS18235 3714258..3715025 - 768 WP_000333379.1 class II glutamine amidotransferase -
ECOLC_RS18240 3715231..3715809 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3711218..3731891 20673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T22671 WP_000615979.1 NC_010468:3713113-3713391 [Escherichia coli ATCC 8739]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T22671 NC_010468:3713113-3713391 [Escherichia coli ATCC 8739]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT22671 WP_000729704.1 NC_010468:3712850-3713110 [Escherichia coli ATCC 8739]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT22671 NC_010468:3712850-3713110 [Escherichia coli ATCC 8739]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References