226670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 739068..739843 Replicon chromosome
Accession NZ_CP088120
Organism Klebsiella pneumoniae strain 46

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag LRM33_RS03690 Protein ID WP_004150910.1
Coordinates 739358..739843 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag LRM33_RS03685 Protein ID WP_004150912.1
Coordinates 739068..739361 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM33_RS03665 (LRM33_03665) 734276..734878 - 603 WP_002916735.1 short chain dehydrogenase -
LRM33_RS03670 (LRM33_03670) 734976..735887 + 912 WP_004188550.1 LysR family transcriptional regulator -
LRM33_RS03675 (LRM33_03675) 735888..737036 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
LRM33_RS03680 (LRM33_03680) 737047..738423 - 1377 WP_004217775.1 cystathionine beta-synthase -
LRM33_RS03685 (LRM33_03685) 739068..739361 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
LRM33_RS03690 (LRM33_03690) 739358..739843 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
LRM33_RS03695 (LRM33_03695) 740547..741140 + 594 WP_004188553.1 hypothetical protein -
LRM33_RS03700 (LRM33_03700) 741237..741453 + 217 Protein_727 transposase -
LRM33_RS03705 (LRM33_03705) 742059..742931 + 873 WP_004188557.1 ParA family protein -
LRM33_RS03710 (LRM33_03710) 742931..743314 + 384 WP_004150906.1 hypothetical protein -
LRM33_RS03715 (LRM33_03715) 743307..744674 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 741237..741389 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T226670 WP_004150910.1 NZ_CP088120:739358-739843 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T226670 NZ_CP122597:c18889-18509 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTTCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT226670 WP_004150912.1 NZ_CP088120:739068-739361 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT226670 NZ_CP122597:c19110-18889 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References