Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 1590555..1591089 | Replicon | plasmid pRRI128_1 |
| Accession | NZ_CP088114 | ||
| Organism | Sinorhizobium meliloti strain RRI128 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | SmelRRI128_RS25345 | Protein ID | WP_017268214.1 |
| Coordinates | 1590555..1590851 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | H0FXK0 |
| Locus tag | SmelRRI128_RS25350 | Protein ID | WP_003527850.1 |
| Coordinates | 1590841..1591089 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SmelRRI128_RS25310 (SmelRRI128_25310) | 1586122..1587501 | - | 1380 | WP_027988292.1 | sodium:alanine symporter family protein | - |
| SmelRRI128_RS25315 (SmelRRI128_25315) | 1587734..1587877 | - | 144 | WP_153318136.1 | hypothetical protein | - |
| SmelRRI128_RS25320 (SmelRRI128_25320) | 1588035..1588244 | - | 210 | WP_003527838.1 | dodecin family protein | - |
| SmelRRI128_RS25325 (SmelRRI128_25325) | 1588534..1588980 | + | 447 | WP_014527651.1 | DNA-binding protein | - |
| SmelRRI128_RS25330 (SmelRRI128_25330) | 1588984..1589169 | - | 186 | WP_014527652.1 | hypothetical protein | - |
| SmelRRI128_RS25335 (SmelRRI128_25335) | 1589336..1589734 | - | 399 | WP_010974988.1 | hypothetical protein | - |
| SmelRRI128_RS25340 (SmelRRI128_25340) | 1590216..1590476 | + | 261 | Protein_1455 | helix-turn-helix domain-containing protein | - |
| SmelRRI128_RS25345 (SmelRRI128_25345) | 1590555..1590851 | - | 297 | WP_017268214.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SmelRRI128_RS25350 (SmelRRI128_25350) | 1590841..1591089 | - | 249 | WP_003527850.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| SmelRRI128_RS25355 (SmelRRI128_25355) | 1591708..1591833 | + | 126 | Protein_1458 | IS481 family transposase | - |
| SmelRRI128_RS25360 (SmelRRI128_25360) | 1591917..1592711 | - | 795 | WP_014527654.1 | methyltransferase domain-containing protein | - |
| SmelRRI128_RS25365 (SmelRRI128_25365) | 1592715..1593515 | - | 801 | WP_014527655.1 | ABC transporter ATP-binding protein | - |
| SmelRRI128_RS25370 (SmelRRI128_25370) | 1593512..1594555 | - | 1044 | WP_010974980.1 | iron ABC transporter permease | - |
| SmelRRI128_RS25375 (SmelRRI128_25375) | 1594552..1595619 | - | 1068 | WP_010974979.1 | ABC transporter substrate-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Mobilizable plasmid | - | htpB | 1..1607182 | 1607182 | ||
| - | flank | IS/Tn | - | - | 1591642..1591833 | 191 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11490.20 Da Isoelectric Point: 10.7543
>T226645 WP_017268214.1 NZ_CP088114:c1590851-1590555 [Sinorhizobium meliloti]
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL
Download Length: 297 bp
>T226645 NZ_CP122588:1105168-1105503 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 8888.73 Da Isoelectric Point: 4.2176
>AT226645 WP_003527850.1 NZ_CP088114:c1591089-1590841 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD
Download Length: 249 bp
>AT226645 NZ_CP122588:1104920-1105168 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|