226644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1234698..1235365 Replicon plasmid pRRI128_1
Accession NZ_CP088114
Organism Sinorhizobium meliloti strain RRI128

Toxin (Protein)


Gene name vapC Uniprot ID A0A7X2CQG3
Locus tag SmelRRI128_RS23630 Protein ID WP_014527488.1
Coordinates 1234922..1235365 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag SmelRRI128_RS23625 Protein ID WP_010975287.1
Coordinates 1234698..1234925 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmelRRI128_RS23605 (SmelRRI128_23605) 1230092..1230973 - 882 WP_014527484.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
SmelRRI128_RS23610 (SmelRRI128_23610) 1231091..1232383 - 1293 WP_014527485.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
SmelRRI128_RS23615 (SmelRRI128_23615) 1232752..1234041 + 1290 WP_014527486.1 SDR family oxidoreductase -
SmelRRI128_RS23620 (SmelRRI128_23620) 1234041..1234514 + 474 WP_014527487.1 DUF2269 family protein -
SmelRRI128_RS23625 (SmelRRI128_23625) 1234698..1234925 + 228 WP_010975287.1 hypothetical protein Antitoxin
SmelRRI128_RS23630 (SmelRRI128_23630) 1234922..1235365 + 444 WP_014527488.1 PIN domain-containing protein Toxin
SmelRRI128_RS23635 (SmelRRI128_23635) 1235381..1236319 - 939 WP_010975284.1 choline ABC transporter substrate-binding protein -
SmelRRI128_RS23640 (SmelRRI128_23640) 1236388..1237218 - 831 WP_014527489.1 SDR family oxidoreductase -
SmelRRI128_RS23645 (SmelRRI128_23645) 1237215..1237712 - 498 WP_010975282.1 acetone carboxylase subunit gamma -
SmelRRI128_RS23650 (SmelRRI128_23650) 1237716..1239908 - 2193 WP_014527490.1 hydantoinase B/oxoprolinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1607182 1607182


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15592.86 Da        Isoelectric Point: 6.6378

>T226644 WP_014527488.1 NZ_CP088114:1234922-1235365 [Sinorhizobium meliloti]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPAMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T226644 NZ_CP122588:762688-763068 [Escherichia coli]
ATGAAAACATTACCCGACACTCACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCTCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATCCTCCGGGCCCGCAGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT226644 WP_010975287.1 NZ_CP088114:1234698-1234925 [Sinorhizobium meliloti]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT226644 NZ_CP122588:762231-762599 [Escherichia coli]
GTGTCAGACACACTCCATGAGACAAATTATCCCAACGACAATCACAACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGACGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGGCACTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGATATGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2CQG3

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References