Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 4740507..4741858 | Replicon | chromosome |
| Accession | NZ_CP088019 | ||
| Organism | Pectobacterium carotovorum strain 25.1 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | LQF52_RS21450 | Protein ID | WP_039546300.1 |
| Coordinates | 4740818..4741858 (+) | Length | 347 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | A0A7V8TEI5 |
| Locus tag | LQF52_RS21445 | Protein ID | WP_039474444.1 |
| Coordinates | 4740507..4740821 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQF52_RS21425 (LQF52_21425) | 4736139..4737842 | + | 1704 | WP_039546318.1 | ABC transporter ATP-binding protein | - |
| LQF52_RS21430 (LQF52_21430) | 4737844..4738878 | + | 1035 | WP_039546309.1 | putative FMN-dependent luciferase-like monooxygenase | - |
| LQF52_RS21435 (LQF52_21435) | 4738875..4740008 | + | 1134 | WP_039546306.1 | alkylhydroperoxidase domain protein | - |
| LQF52_RS21440 (LQF52_21440) | 4740196..4740522 | + | 327 | WP_039546304.1 | helix-turn-helix domain-containing protein | - |
| LQF52_RS21445 (LQF52_21445) | 4740507..4740821 | + | 315 | WP_039474444.1 | HipA N-terminal domain-containing protein | Antitoxin |
| LQF52_RS21450 (LQF52_21450) | 4740818..4741858 | + | 1041 | WP_039546300.1 | HipA domain-containing protein | Toxin |
| LQF52_RS21455 (LQF52_21455) | 4741919..4742542 | - | 624 | WP_039474438.1 | LysE family translocator | - |
| LQF52_RS21460 (LQF52_21460) | 4742821..4743576 | + | 756 | WP_039546298.1 | thiol:disulfide interchange protein DsbG | - |
| LQF52_RS21465 (LQF52_21465) | 4743611..4744516 | - | 906 | WP_231051788.1 | siderophore-interacting protein | - |
| LQF52_RS21470 (LQF52_21470) | 4744774..4745025 | + | 252 | WP_039533012.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LQF52_RS21475 (LQF52_21475) | 4745022..4745309 | + | 288 | WP_039533010.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LQF52_RS21480 (LQF52_21480) | 4745412..4746764 | - | 1353 | WP_040032226.1 | glutathione-disulfide reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 347 a.a. Molecular weight: 39552.52 Da Isoelectric Point: 6.5016
>T226587 WP_039546300.1 NZ_CP088019:4740818-4741858 [Pectobacterium carotovorum]
MTRCRILLTPLTHEEESATGYSRKGLKHLTGSMHASPALRFTRQQFMLDLPQTQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI
MTRCRILLTPLTHEEESATGYSRKGLKHLTGSMHASPALRFTRQQFMLDLPQTQKGMSISGYQPKIQMVLEERAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKIHTDGRQYVSYERLALFLSKHVNDNIVFKIDLFRRIAYAYMLGNNDMHLRNFGLIHSRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADFLKEAECVESTYRDSFMP
AEAIDTTLRCYRHRLNLMSILDAERI
Download Length: 1041 bp
>T226587 NZ_CP122564:2634930-2635355 [Auritidibacter ignavus]
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGGCGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGACGTGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGCGCCGATCAGTACCGCCGACGCGCAGAC
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGGCGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGACGTGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGCGCCGATCAGTACCGCCGACGCGCAGAC
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11856.65 Da Isoelectric Point: 9.5753
>AT226587 WP_039474444.1 NZ_CP088019:4740507-4740821 [Pectobacterium carotovorum]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQAGTFRSQTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQAGTFRSQTLPPYFASLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKS
Download Length: 315 bp
>AT226587 NZ_CP122564:2634700-2634933 [Auritidibacter ignavus]
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCTGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCTGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|