Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3422821..3423434 Replicon chromosome
Accession NZ_CP088008
Organism Tardiphaga sp. 37S4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LPB73_RS16375 Protein ID WP_231077552.1
Coordinates 3423138..3423434 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPB73_RS16370 Protein ID WP_089267874.1
Coordinates 3422821..3423129 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB73_RS16350 (LPB73_16350) 3418343..3418945 - 603 WP_068738457.1 LysE family translocator -
LPB73_RS16355 (LPB73_16355) 3418950..3419822 - 873 WP_231077550.1 EamA family transporter -
LPB73_RS16360 (LPB73_16360) 3419841..3420383 - 543 WP_068738461.1 acetolactate synthase small subunit -
LPB73_RS16365 (LPB73_16365) 3420547..3422325 - 1779 WP_231077551.1 acetolactate synthase 3 large subunit -
LPB73_RS16370 (LPB73_16370) 3422821..3423129 - 309 WP_089267874.1 HigA family addiction module antitoxin Antitoxin
LPB73_RS16375 (LPB73_16375) 3423138..3423434 - 297 WP_231077552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPB73_RS16380 (LPB73_16380) 3423475..3424401 - 927 WP_231077553.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
LPB73_RS16385 (LPB73_16385) 3424405..3425295 + 891 WP_231077554.1 phosphoserine phosphatase SerB -
LPB73_RS16390 (LPB73_16390) 3426325..3427863 - 1539 WP_120289070.1 Do family serine endopeptidase -
LPB73_RS16395 (LPB73_16395) 3428062..3428262 - 201 WP_068734021.1 DUF2065 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-95)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11619.99 Da        Isoelectric Point: 6.8803

>T226560 WP_231077552.1 NZ_CP088008:c3423434-3423138 [Tardiphaga sp. 37S4]
MIVGFRDDWLRAFFVDDVHSRNIPADLESRLFRKLQMIDDATTDQDLRVPPSNHFEKLRGKLGGSHSIRVNNQWRLIFRW
DSSRGEASDLYLDDHSYR

Download         Length: 297 bp

>T226560 NZ_CP122517:872590-872997 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11402.31 Da        Isoelectric Point: 10.5874

>AT226560 WP_089267874.1 NZ_CP088008:c3423129-3422821 [Tardiphaga sp. 37S4]
MLMTKRKPATVGEILVEEFMQPLGLTQGTLAKAMGVQRKHVNELCNDRRNVTAATALILARVFGNSPDFWLNVQRRGDLW
EAMNSPQELARIERATPLVKAA

Download         Length: 309 bp

>AT226560 NZ_CP122517:872343-872609 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References