226557

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 109200..109879 Replicon chromosome
Accession NZ_CP088007
Organism Nocardia huaxiensis strain BCHNH01

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag LPY97_RS00535 Protein ID WP_231084572.1
Coordinates 109607..109879 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LPY97_RS00530 Protein ID WP_181581149.1
Coordinates 109200..109517 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPY97_RS00515 (LPY97_00515) 104696..108100 + 3405 WP_181581152.1 pyruvate carboxylase -
LPY97_RS00520 (LPY97_00520) 108168..108725 + 558 WP_181581151.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
LPY97_RS00525 (LPY97_00525) 108735..109166 - 432 WP_231084571.1 hypothetical protein -
LPY97_RS00530 (LPY97_00530) 109200..109517 - 318 WP_181581149.1 helix-turn-helix transcriptional regulator Antitoxin
LPY97_RS00535 (LPY97_00535) 109607..109879 - 273 WP_231084572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPY97_RS00540 (LPY97_00540) 110415..110684 + 270 WP_181581147.1 acyltransferase -
LPY97_RS00545 (LPY97_00545) 110689..111408 + 720 WP_231084573.1 VTT domain-containing protein -
LPY97_RS00550 (LPY97_00550) 111418..111903 + 486 WP_181581145.1 pantetheine-phosphate adenylyltransferase -
LPY97_RS00555 (LPY97_00555) 111981..112970 - 990 WP_231084574.1 hypothetical protein -
LPY97_RS00560 (LPY97_00560) 113106..113624 - 519 WP_181581143.1 GtrA family protein -
LPY97_RS00565 (LPY97_00565) 113920..114666 + 747 WP_181581142.1 DivIVA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10091.50 Da        Isoelectric Point: 4.6028

>T226557 WP_231084572.1 NZ_CP088007:c109879-109607 [Nocardia huaxiensis]
MADQEWDIYIVDEVRQWIERLDEPTFRRVVEAIDALADGGPGLGRPLVDSIAGSKVSNMKELRPGTVRILFAFDPWRSSV
LLAAGDKVHQ

Download         Length: 273 bp

>T226557 NZ_CP122517:265319-265549 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11500.11 Da        Isoelectric Point: 10.2895

>AT226557 WP_181581149.1 NZ_CP088007:c109517-109200 [Nocardia huaxiensis]
MSGHVRWQDIRAEMVDRAGGEAAVAKGKDELLAQVRGQRLADIRRRRGLTQLQVADRMGVTKGRVSQIEQGTVTGQEVLA
RYALALGGRLHQSIYFDDGDIVAIA

Download         Length: 318 bp

>AT226557 NZ_CP122517:265546-265905 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References